Acyclovir mechanism of action PDF vantin

Aciclovir sodium C 8H 10N 5NaO 3 Relative molecular mass: 247.19 1.1.3 Chemical and physical properties of the pure substances Aciclovir (a) Description: White, crystalline powder (American Hospital Formulary Service,1999) (b) Melting-point: 256.5–257 °C (Budavari, 1996)(c) Spectroscopy data: Infrared spectral data have been reported (British Pharma-copoeial Commission, 1993).
The drug and its metabolites are excreted by the kidney via glomerular filtration and tubular secretion. Intravenous acyclovir is effective for mucocutaneous herpes infections in the compromised host and initial genital herpes in the normal host; it is being evaluated for the treatment of herpes simplex virus encephalitis and varicella‐zoster infections. The most important adverse effect is crystalluria and elevated serum creatinine related to bolus intravenous administration. The drug may be administered topically to the skin, intravenously, orally, or topically to the eye (only topical and intravenous preparations are currently available). and It shows good in vitro activity against herpes simplex and varicella‐zoster viruses.
The most important adverse effect is crystalluria and elevated serum creatinine related to bolus intravenous administration. An investigational oral preparation may prove to be effective therapy for both initial and recurrent genital herpes. Wellcome Research Laboratories, Research Triangle Park, North Carolina. Dosage adjustment is required in patients with renal failure.



It shows good in vitro activity against herpes simplex and varicella‐zoster viruses.



The discovery that acyclovir (acyclo-Guo, 9-(2-hydroxyefhoxymethyl)guanine) was a potent inhibitor of the replication of herpes simplex virus types 1 and 2 (HSV-1, HSV-2) with very low toxicity for the host cells [1,2] led to an extensive investigation of its mechanism of action and selec- … Show details Pharmacotherapy Actions. MECHANISM OF ACTION; Acyclovir is a pro drug, it needs phosphorylation for its activation.

Activity, Tolerability, and Mechanism of Action of BX795 as an Antiviral against Herpes Simplex Virus 2 Genital Infection Highly effective and safe polymeric inhibitors of herpes simplex virus



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