Amantadine with abilify

The administration of Amantadine tablets as a 200 mg single dose to 6 healthy subjects resulted in a Cmax of 0.51 ± 0.14 mcg/mL. Care should be exercised when administering Amantadine to patients with a history of recurrent eczematoid rash, or to patients with psychosis or severe psychoneurosis not controlled by chemotherapeutic agents.Serious bacterial infections may begin with influenza-like symptoms or may coexist with or occur as complications during the course of influenza. The daily dosage may be split into one capsule of 100 mg twice a day. Patients may be unable to control these urges while taking one or more of the medications that are generally used for the treatment of Parkinson's disease and that increase central dopaminergic tone, including Amantadine hydrochloride. However, in two non-GLP studies in rats in which females were dosed from 5 days prior to mating to Day 6 of gestation or on Days 7 to 14 of gestation, Amantadine produced increases in embryonic death at an oral dose of 100 mg/kg (or 3 times the maximum recommended human dose on a mg/m Amantadine should be used during pregnancy only if the potential benefit justifies the potential risk to the embryo or fetus.Amantadine is excreted in human milk. It may result in toxicity of the heart, lungs, kidneys, or central nervous system.Amantadine overdose has occurred in people with impaired kidney function who are not able to excrete the drug thoroughly.The kidneys primarily excrete amantadine via the urine. Does Amantadine Interact with other Medications? Cardiac dysfunction includes arrhythmia, tachycardia and hypertension.

Amantadine hydrochloride, USP has pharmacological actions as both an anti-Parkinson and an antiviral drug.Amantadine hydrochloride, USP is available as 100 mg capsules for oral administration. Amantadine is a drug that helps treat Parkinson’s disease and other conditions. It has very little or no activity against influenza B virus isolates. Because of the possibility of serious adverse effects, caution should be observed when prescribing Amantadine hydrochloride capsules to patients being treated with drugs having CNS effects, or for whom the potential risks outweigh the benefit of treatment.Patients with a history of epilepsy or other "seizures" should be observed closely for possible increased seizure activity.Patients receiving Amantadine hydrochloride capsules who note central nervous system effects or blurring of vision should be cautioned against driving or working in situations where alertness and adequate motor coordination are important.Patients with a history of congestive heart failure or peripheral edema should be followed closely as there are patients who developed congestive heart failure while receiving Amantadine hydrochloride capsules.Patients with Parkinson's disease improving on Amantadine hydrochloride capsules should resume normal activities gradually and cautiously, consistent with other medical considerations, such as the presence of osteoporosis or phlebothrombosis.Because Amantadine Hydrochloride Capsules, USP has anticholinergic effects and may cause mydriasis, it should not be given to patients with untreated angle closure glaucoma.Sporadic cases of possible Neuroleptic Malignant Syndrome (NMS) have been reported in association with dose reduction or withdrawal of Amantadine therapy.

There are no well-controlled clinical studies demonstrating that treatment with Amantadine hydrochloride capsules, USP will avoid the development of influenza A virus pneumonitis or other complications in high risk patients.There is no clinical evidence indicating that Amantadine hydrochloride capsules, USP are effective in the prophylaxis or treatment of viral respiratory tract illnesses other than those caused by influenza A virus strains.The following points should be considered before initiating treatment or prophylaxis with Amantadine hydrochloride capsules, USP.Amantadine hydrochloride capsules, USP are indicated in the treatment of idiopathic Parkinson's disease (Paralysis Agitans), postencephalitic parkinsonism and symptomatic parkinsonism which may follow injury to the nervous system by carbon monoxide intoxication. Severe Interactions. Therefore, patients should be observed carefully when the dosage of Amantadine is reduced abruptly or discontinued, especially if the patient is receiving neuroleptics.NMS is an uncommon but life-threatening syndrome characterized by fever or hyperthermia; neurologic findings including muscle rigidity, involuntary movements, altered consciousness; mental status changes; other disturbances such as autonomic dysfunction, tachycardia, tachypnea, hyper- or hypotension; laboratory findings such as creatine phosphokinase elevation, leukocytosis, myoglobinuria, and increased serum myoglobin.The early diagnosis of this condition is important for the appropriate management of these patients. Dopamine agonists, such as bromocriptine, and muscle relaxants, such as dantrolene are often used in the treatment of NMS, however, their effectiveness has not been demonstrated in controlled studies.Because Amantadine is mainly excreted in the urine, it accumulates in the plasma and in the body when renal function declines. Seizures may be exacerbated in patients with prior history of seizure disorders. Drug overdose has resulted in cardiac, respiratory, renal or central nervous system toxicity. Amantadine is well tolerated in children and adolescents, with an acceptable side effect profile, and considered safe for long term use.

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