Clopidogrel angioedema

This can be managed with oral steroids without clopidogrel discontinuation.



Hypersensitivity including rash, angioedema or hematologic reaction have been reported in patients receiving clopidogrel bisulfate, including patients with a history of hypersensitivity or hematologic reaction to other thienopyridines [see Contraindications (4.2) and Adverse Reactions (6.2)]. Desensitization protocols and alternative regimens (e.g., clopidogrel, prasugrel, and addition of an adjunctive anticoagulant) should be considered when there is an absolute indication for antiplatelet therapy.The benefit of dual antiplatelet therapy (DAPT) following an acute coronary syndrome (ACS) was established by several pivotal trials [Clopidogrel has become a mainstay of treatment of patients with ACS to reduce ischemic complications after percutaneous coronary interventions. Fischer TC, Worm M, Groneberg DA. Clopidogrel induced urticarial rash in a patient with left main stem percutaneous coronary intervention: management issues. Complete resolution of hypersensitivity reaction was observed in 61 patients (98%) with a short course of oral prednisone. Clopidogrel, an oral thienopyridine prodrug, is generally well tolerated, but 1.5% of patients eventually require drug discontinuation [With respect to the clinical scenario warranting dual antiplatelet therapy for a protracted period, several therapeutic options can be considered. The mean age was 62 ± 11 years, 71% of patients were male, and 35% reported prior adverse drug reaction.

Hope, Trinidad and TobagoAdvanced Cardiovascular Institute, Port of Spain, Trinidad and Tobago

Angioedema can cause potentially life-threatening airway obstruction. Campbell KL, Cohn JR, Savage MP. His cardiac biomarkers were normal (peak serum levels of creatine phosphokinase-MB fraction (CK-MB) and troponin T were 1.5 ng mLApproximately 1 hour after ticagrelor administration, the patient reported a constellation of symptoms which included worsening chest pain, sudden-onset respiratory distress, and generalized urticaria. Rajeev Seecheran, Valmiki Seecheran, Sangeeta Persad, Sasha Lalla, Naveen Anand SeecheranAngioedema can cause potentially life-threatening airway obstruction. Clopidogrel monotherapy is recommended as an option to prevent occlusive vascular events in patients who have had: an ischaemic stroke, or who have peripheral arterial disease or multivascular disease, or; a myocardial infarction, only if aspirin is contra-indicated or not tolerated. ScienceDirect ® is a registered trademark of Elsevier B.V.Characterization of Clopidogrel Hypersensitivity Reactions and Management With Oral Steroids Without Clopidogrel DiscontinuationCopyright © 2011 American College of Cardiology Foundation. Am J Med 2003; 114:77.
Cutaneous testing was performed after completion of clopidogrel therapy for diagnosis and assessment of cross-reactivity.Sixty-two patients representing 1.6% of the percutaneous coronary intervention population developed clopidogrel hypersensitivity during the study period. This is an open access article distributed under the We are committed to sharing findings related to COVID-19 as quickly and safely as possible. clopidogrel and other thienopyridines (prasugrel and ticlopidine), which are antiplatelet agents commonly used in the management of patients with cardiovascular disease, may cause hypersensitivity reactions, most commonly cutaneous rashes and more rarely, generalized reactions with urticaria, fever, arthralgia, angioedema or hematologic toxicity 1,2,3 There were no acute ischemic changes.

Vascular permeability is a proposed pathological feature of COVID-19, and the dry cough has been remarked to resemble the idiopathic cough seen in 10–15% of patients who receive angiotensin-converting enzyme (ACE) inhibitors.
His clinical angioedema completely resolved.

Published by Elsevier Inc. All rights reserved.ScienceDirect ® is a registered trademark of Elsevier B.V.

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