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These substudies did not evaluate the effects of CE-alone or CE plus MPA on menopausal symptoms.The WHI estrogen-alone substudy was stopped early because an increased risk of stroke was observed, and it was deemed that no further information would be obtained regarding the risks and benefits of estrogen-alone in predetermined primary endpoints. Since the ancillary study was conducted in women 65 to 79 years of age, it is unknown whether these findings apply to younger postmenopausal women When data from the 2 populations were pooled as planned in the WHIMS protocol, the reported overall relative risk for probable dementia was 1.76 (95 percent CI, 1.19 to 2.60).
1 star 2 stars 3 stars 4 stars 5 stars. If estrogen is administered to patients whose bone growth is not complete, periodic monitoring of bone maturation and effects on epiphyseal centers is recommended during estrogen administration.Estrogen treatment of prepubertal girls also induces premature breast development and vaginal cornification, and may induce vaginal bleeding.There have not been sufficient numbers of geriatric women involved in clinical studies utilizing DOTTI to determine whether those over 65 years of age differ from younger subjects in their response to DOTTI.In the WHI estrogen-alone substudy (daily CE [0.625 mg]-alone versus placebo), there was a higher relative risk of stroke in women greater than 65 years of age In the WHI estrogen plus progestin substudy (daily CE [0.625 mg] plus MPA [2.5 mg] versus placebo), there was a higher relative risk of nonfatal stroke and invasive breast cancer in women greater than 65 years of age In the WHIMS ancillary studies of postmenopausal women 65 to 79 years of age, there was an increased risk of developing probable dementia in women receiving estrogen-alone or estrogen plus progestin when compared to placebo Since both ancillary studies were conducted in women 65 to 79 years of age, it is unknown whether these findings apply to younger postmenopausal women The effect of renal impairment on the pharmacokinetics of DOTTI has not been studied.The effect of hepatic impairment on the pharmacokinetics of DOTTI has not been studied.Overdosage of estrogen may cause nausea, vomiting, breast tenderness, abdominal pain, drowsiness and fatigue, and withdrawal bleeding may occur in women. In some women the symptoms are mild, and they will not need estrogens. If angioedema involves the tongue, glottis, or larynx, airway obstruction may occur. It is mostly used as hormone replacement in menopausal women. For women with a history of cholestatic jaundice associated with past estrogen use or with pregnancy, caution should be exercised, and in the case of recurrence, medication should be discontinued.Estrogen administration leads to increased thyroid-binding globulin (TBG) levels. If you have or have had cancer, talk with your healthcare provider about whether you should use DOTTI.See the list of ingredients in DOTTI at the end of this leaflet.DOTTI is not for pregnant women. Consider discontinuation of treatment if pancreatitis occurs. The sudden drop in estrogen levels causes “surgical menopause.”When the estrogen levels begin dropping, some women develop very uncomfortable symptoms, such as feelings of warmth in the face, neck, and chest or sudden strong feelings of heat and sweating (“hot flashes” or “hot flushes”). These opinions do not represent the opinions of WebMD. found this review helpful.Reviewer: Rmlong , 55-64 on Treatment for 6 months to less than 1 year (Patient) 0 Inform postmenopausal women of the importance of reporting unusual vaginal bleeding to their healthcare providers as soon as possible Inform postmenopausal women of possible serious adverse reactions of estrogen-alone therapy including Cardiovascular Disorders, Malignant Neoplasms, and Probable Dementia Inform postmenopausal women of possible less serious but common adverse reactions of estrogen-alone therapy such as headache, breast pain and tenderness, nausea and vomiting.

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