Glucophage SR weight loss lopressor

Glucophage may be used with other oral medications or insulin to control diabetes 1. In post marketing data and in controlled clinical studies, adverse event reporting in patients treated with Glucophage SR was similar in nature and severity to that reported in patients treated with Glucophage immediate release.During treatment initiation, the most common adverse reactions are nausea, vomiting, diarrhoea, abdominal pain and loss of appetite, which resolve spontaneously in most cases.The following adverse reactions may occur with Glucophage SR.Frequencies are defined as follows: very common: >1/10; common ≥1/100, <1/10; uncommon ≥1/1,000, <1/100; rare ≥1/10,000, <1/1,000; very rare <1/10,000.Within each frequency grouping, adverse reactions are presented in order of decreasing seriousness. • Reduction in the risk or delay of the onset of type 2 diabetes mellitus in adult, overweight patients with IGT* and/or IFG*, and/or increased HbA1C who are:- at high risk for developing overt type 2 diabetes mellitus (see section 5.1) and- still progressing towards type 2 diabetes mellitus despite implementation of intensive lifestyle change for 3 to 6 months Treatment with Glucophage SR must be based on a risk score incorporating appropriate measures of glycaemic control and including evidence of high cardiovascular risk (see section 5.1).Lifestyle modifications should be continued when metformin is initiated, unless the patient is unable to do so because of medical reasons. • Dosage increases should be made in increments of 500mg every 10-15 days, up to a maximum of 2000mg once daily with the evening meal. If glycaemic control is still not achieved, patients may be switched to standard metformin tablets to a maximum dose of 3000 mg daily.

Glucophage SR may be used as monotherapy or in combination with other oral antidiabetic agents, or with insulin.

No prospective comparative data for metformin on macrovascular outcomes in patients with IGT and/or IFG and/or increased HbAPublished risk factors for type 2 diabetes include: Asian or black ethnic background, age above 40, dyslipidaemia, hypertension, obesity or being overweight, age, 1st degree family history of diabetes, history of gestational diabetes mellitus, and polycystic ovary syndrome (PCOS).Consideration must be given to current national guidance on the definition of prediabetes.Patients at high risk should be identified by a validated risk-assessment tool.The prospective randomised (UKPDS) study has established the long-term benefit of intensive blood glucose control in overweight type 2 diabetic patients treated with immediate release metformin as first-line therapy after diet failure. • Gastrointestinal disorders such as nausea, vomiting, diarrhoea, abdominal pain and loss of appetite. • Isolated reports of liver function tests abnormalities or hepatitis resolving upon metformin discontinuation. Any unused product or waste material should be disposed of in accordance with local requirements.Merck Serono Ltd, 5 New Square, Bedfont Lakes Business Park, Feltham, Middlesex, TW14 8HA, UKTo bookmark a medicine you must sign up and log in.To view the changes to a medicine you must sign up and log in. Avoiding obesity is a matter of avoiding […] Special warnings and precautions for use). When starting or using such products in combination with metformin, close monitoring of renal function is necessary.More frequent blood glucose monitoring may be required, especially at the beginning of treatment. A decision on whether to discontinue breast-feeding should be made, taking into account the benefit of breast-feeding and the potential risk to adverse effect on the child.Fertility of male or female rats was unaffected by metformin when administered at doses as high as 600 mg/kg/day, which is approximately three times the maximum recommended human daily dose based on body surface area comparisons.Metformin monotherapy does not cause hypoglycaemia and therefore has no effect on the ability to drive or to use machines.However, patients should be alerted to the risk of hypoglycaemia when metformin is used in combination with other antidiabetic agents (e.g.

• Inhibitors of both OCT1 and OCT2 (such as crizotinib, olaparib) may alter efficacy and renal elimination of metformin.Caution is therefore advised, especially in patients with renal impairment, when these drugs are co-administered with metformin, as metformin plasma concentration may increase. • Inhibitors of OCT2 (such as cimetidine, dolutegravir, ranolazine, trimethoprim, vandetanib, isavuconazole) may decrease the renal elimination of metformin and thus lead to an increase in metformin plasma concentration. • It is recommended to regularly monitor (every 3-6 months) the glycaemic status (OGTT and/or FPG and/or HbA1c value) as well as the risk factors to evaluate whether treatment needs to be continued, modified or discontinued.

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