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There was a trend towards higher levels of CRP and ESR in ME/CFS, and particularly in those with mild/moderate disease.CK levels were found to be good predictors of severe ME/CFS cases as compared to those who were less severely-affected or healthy controls; this was enhanced by the inclusion of other laboratory tests results in the model.Cellular energy is mainly generated from the breakdown of the high-energy molecule, adenosine triphosphate (ATP). Article by Miriam Tucker New Findings Elucidate Potentially Treatable aspects of ME/CFS - Medscape - Apr 10, 2019, published on ME Association.

8. Thought it might be nice to have a list of the best and/or biggest ME articles of 2019 in main stream media.

I first learned about Mestinon doing research on things that help ME/CFS in 2017.

Highlights recent biomedical findings. –and apparently can help ME/CFS patients! This article by Miriam Tucker also appeared in Medscape a week ago (4/9/2019) re the NIH ME/CFS April 2019 Conference.. Moreover, a “high-normal” result in people who are often sedentary or bedbound, particularly those with severe ME/CFS, should be interpreted with caution, as it could indicate the presence of muscle injury.How has your M.E affected your attendance at school, college, or university during the past academic year, prior to lockdown?Available every day of the week between these times: 10am - 12noon, 2pm - 4pm and 7pm - 9pm.Calls cost the same as other standard landline numbers (starting 01 or 02).

Myalgic encephalomyelitis/chronic fatigue syndrome has become the focus of serious attention by the NIH, and funded research is showing results, but … Here's a start.

This article is titled -“'Milestone' Meeting Highlights NIH Efforts to Combat ME/CFS”“New Findings Elucidate Potentially Treatable Aspects of ME/CFS”“New Findings Elucidate Potentially Treatable Aspects of ME/CFS” In this analytical cross-sectional study, we aimed to explore potential haematological and biochemical markers for ME/CFS, and disease severity.We reviewed laboratory test results from 272 people with ME/CFS and 136 healthy controls participating in the UK ME/CFS Biobank (UKMEB).After corrections for multiple comparisons, most results were within the normal range, but people with severe ME/CFS presented with lower median values (p < 0.001) of serum creatine kinase (CK; median = 54 U/L), compared to healthy controls (HCs; median = 101.5 U/L) and non-severe ME/CFS (median = 84 U/L).The differences in CK concentrations persisted after adjusting for sex, age, body mass index, muscle mass, disease duration, and activity levels (odds ratio (OR) for being a severe case = 0.05 (95% confidence interval (CI) = 0.02–0.15) compared to controls, and OR = 0.16 (95% CI = 0.07–0.40), compared to mild cases).In this study we compared baseline laboratory tests results from UKMEB participants with ME/CFS, including mildly/moderately and severely affected (i.e., house-bound or bed-bound) individuals, and healthy controls, which were collected as part of the routine workup of participants.This study included a sample of 272 confirmed ME/CFS cases and 136 healthy controls.

JavaScript is disabled. Nevertheless, the persistent significant association between lower serum CK and disease severity in the multivariate model that controls for activity suggests that these results cannot be fully explained by reduced physical activity, but that there are other factors involved.Further investigations with a larger sample size and more detailed explorations of metabolic pathways will be needed to confirm whether low CK activity is a primary or secondary event in ME/CFS or, indeed, whether it reflects some other metabolic dysfunction.This could benefit from the use of “diseased” controls groups, such as selected orthopaedic patients with prolonged immobility.

New Findings Elucidate Potentially Treatable Aspects of ME/CFS Circulatory defects and orthostatic intolerance are common and potentially treatable manifestations of the illness.

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