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The terminal half-life was significantly increased. Itraconazole capsules should not be used in paediatric patients unless the potential benefit outweighs the potential risks.Clinical data on the use of itraconazole in elderly patients is limited. For information on patients with achlorhydria and patients on acid secretion suppressors or taking acid neutralising medicinal products (see section 4.4).Itraconazole is for oral administration and must be taken immediately after a meal for maximal absorption.Itraconazole is contraindicated in patients with known hypersensitivity to the active substance or to any of the excipients listed in section 6.1.Co-administration of the following substances is contraindicated with Itraconazole (see also section 4.5):- substrates metabolized via cytochrome P450 3A4, that can prolong the QT interval, such as astemizole, bepridil, cisapride, dofetilide, levacetylmethadole (levomethadyl), mizolastine, pimozide, quinidine, sertindole and terfenadine. Opaque green capsule, containing yellowish-beige beads. You simply … Renal excretion of the parent drug accounts for less than 0.03% of the dose, whereas fecal excretion of unchanged drug varies between 3 – 18% of the dose. 2. For the full list of excipients, see section 6.1. Check for information and there availability at your nearest Medplus Store in your locality. As necessary, expert advice should be sought when the local prevalence of resistance is such that the utility of the agent in at least some types of infections is questionable.The tolerability and safety of itraconazole was studied in the prophylaxis of fungal infections in 103 neutropenic paediatric patients aged 0 to 14 years (median 5 years) in an open-label uncontrolled phase III clinical study. When suggestions are available use up and down arrows to review and ENTER to select. Caution should be used in prescribing Itraconazole to patients with hypersensitivity to other azoles.If neuropathy occurs that may be attributable to Itraconazole, the treatment should be discontinued. Caution should be exercised when the drug is administered in this patient population.Two pharmacokinetic studies have been conducted in neutropenic children aged 6 months to 14 years in which itraconazole oral solution was administered 5 mg/kg once or twice daily. Epidemiological data on exposure to itraconazole during the first trimester of pregnancy – mostly in patients receiving short-term treatment for vulvovaginal candidosis – did not show an increased risk for malformations as compared to control subjects not exposed to any known teratogens. tinea pedis, tinea cruris, tinea corporis, tinea manuum. Itraconazole is an antifungal treatment that is used to treat infections caused by fungi and yeasts. If necessary, their dosage should be reduced when administered concomitantly with itraconazole:- HIV protease inhibitors such as indinavir, ritonavir, saquinavir;- certain antineoplastic agents such as busulfan, docetaxel, trimetrexate and vinca alkaloids;- calcium channel blockers metabolized via cytochrome P450 3A4 such as dihydropyridines and verapamil;- certain immunosuppressive agents: ciclosporin, rapamycin (also known as sirolimus) and tacrolimus;- certain glucocorticoids such as budesonide, dexamethasone, fluticasone and methylprednisolone;- others: alfentanil, alprazolam, brotizolam, buspirone, carbamazepine, cilostazole, disopyramide, ebastine, fentanyl, halofantrine, midazolam i.v., reboxetine, repaglinide, rifabutin3.2 No interactions between itraconazole and zidovudine (AZT) or fluvastatin have been observed.No enzyme-inducing effects on the metabolism of ethinylestradiol and norethisterone caused by itraconazole have been observed.Itraconazole must not be used during pregnancy except for life-threatening cases where the potential benefit to the mother outweighs the potential harm to the fetus (see section 4.3). Some of these cases were observed within the first month of treatment, including some within the first week. Your browser is unable to add products to your shopping cart because you have JavaScript disabled. © 2020 Inhouse Pharmacy. Itraconazole is distributed in a large apparent volume in the body (> 700 L), suggesting its extensive distribution into tissues: Concentrations in lung, kidney, liver, bone, stomach, spleen and muscle were found to be two to three times higher than corresponding concentrations in plasma. US Dollars Monitoring of itraconazole trough concentrations in patients treated for fungal infection is recommended. sporanox 100mg capsules 15. drug name: itraconazole product id: 2489824. select a prescription. Peak plasma concentrations of the unchanged drug are reached within 2 to 5 hours following an oral dose. The oral bioavailability of itraconazole may be lower in patients with renal insufficiency. Effective contraception should be continued until the menstrual period following the end of Itraconazol therapy.In some immunosuppressed patients (e.g. The dose should be adapted if necessary. Within each System Organ Class, the adverse drug reactions are presented by incidence, using the following convention:Not known (cannot be estimated from the available data)(frequency cannot be estimated from the available postmarketing data)The safety of itraconazole was evaluated in 250 paediatric patients aged 6 months to 14 years who participated in five open-label clinical trials.

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