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Yet, only a small proportion of those who might benefit from LTBI treatment will start it, and an even smaller proportion will complete it [3]. doi: 10.1097/MD.0000000000004126.Pediatrics. Visitors Upto September 07, 2020: 2344996 Page Last Updated On : July 23, 2018 Designed Developed & Hosted By Content owned & Provided by Central TB Division, Ministry of Health & Family Welfare, Government of India [Best view in Chrome 31.0.1650.63 m,Firefox 27.0,Internet Explorer 8] Page Last Updated On : July 23, 2018 Designed Developed & Hosted By The GDG was composed of a multidisciplinary group of external experts with experience in different aspects of the programmatic management of MDR/RR-TB as well as affected individuals.



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We searched the published literature to discuss (i) standardized versus individualized therapies, including the choice between a single one‐size‐fit‐all regimen versus different options with different key drugs determined mainly by rapid drug susceptibility testing, (ii) alternative regimens for managing drug‐susceptible TB, (iii) evidence for using the World Health Organization (WHO) longer and shorter regimens for multidrug‐resistant TB and (iv) evidence for using repurposed and novel drugs. and you may need to create a new Wiley Online Library account.Enter your email address below and we will send you your usernameIf the address matches an existing account you will receive an email with instructions to retrieve your username

Topical areas of uncertainty on the composition and duration of longer MDR-TB regimens for adults and children, on when the standardized 9-12 month shorter MDR-TB regimen may be offered and the use of culture to monitor treatment response were included in the scope.

Fully oral regimens should thus become the preferred option for most patients.





2020 Dec;79(1):1758501. doi: 10.1080/22423982.2020.1758501.



*3HP = 3 months of once-weekly isoniazid and rifapentine with directly observed therapy; 4R=4 months of rifampin self-administered daily; 9H = 9 months of isoniazid self-administered daily. Clipboard, Search History, and several other advanced features are temporarily unavailable. We hope an easily applicable combination of biomarkers that accurately predict individual treatment outcome will soon be available to ultimately guide individualized therapy.Tuberculosis (TB) is an old disease that dates back to at least 4000 years.The spread of MDR‐TB in numerous low‐ and middle‐income countries has significantly weakened already fragile healthcare systems.

Reliable rapid DST methods should be developed to guide use of novel drugs, as well as pyrazinamide.K.‐C.C.

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