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Should superinfections occur, appropriate measures should be taken as indicated by the clinical situation.Clindamycin dosage modification may not be necessary in patients with renal disease. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy.

Name Clindamycin palmitate hydrochloride Drug Entry Clindamycin. Clindamycin Palmitate Hydrochloride is the palmitate hydrochloride form of clindamycin, a semi-synthetic, chlorinated broad spectrum antibiotic produced by chemical modification of lincomycin.Clindamycin palmitate hydrochloride is used for oral suspension. To reduce the development of drug-resistant bacteria and maintain the effectiveness of clindamycin palmitate hydrochloride for oral solution and other antibacterial drugs, clindamycin palmitate hydrochloride for oral solution should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.Because clindamycin therapy has been associated with severe colitis which may end fatally, it should be reserved for serious infections where less toxic antimicrobial agents are inappropriate, as described in the Clindamycin palmitate hydrochloride is a water soluble hydrochloride salt of the ester of clindamycin and palmitic acid. OK. home message.

There are no adequate and well-controlled studies in pregnant women during the first trimester of pregnancy. Notes: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a … 0000000882 00000 n If oral or intravenous clindamycin is required by a nursing mother, it is not a reason to discontinue breastfeeding, but an alternate drug may be preferred. However, in clinically appropriate circumstances, the physician may elect to initiate treatment or continue treatment with clindamycin palmitate hydrochloride for oral solution.Clindamycin Palmitate Hydrochloride for Oral Solution, USP white to off white flavored granules for oral solution is available in bottles of 100 mL (NDC 23155-603-51).When reconstituted as directed, each bottle yields a solution containing 75 mg of clindamycin per 5 mL.1. H��W[w۸~ׯ�G��(��M�d[[G�Z���&== �l(R%)o���3 HK���S���\��f0�5� 8�_�����Ɓ}3�!�+� Ƕl��F���>Mv#5m�nF��F��'y6$)��>2�L�5�$ ���x�Gn`yx��ZQ��P:�Q�m�R�F��e�#۳ Clindamycin should be dosed based on total body weight regardless of obesity.Serious infections due to anaerobic bacteria are usually treated with clindamycin injection. Therefore, dosage modification in patients with liver disease may not be necessary. In patients with moderate to severe liver disease, prolongation of clindamycin half-life has been found. Clindamycin palmitate hydrochloride Synonym: (2R,3R,4S,5R)-6-(2-Chloro-1-((2S)-1-methyl-4-propylpyrrolidine-2-carboxamido) propyl)-4,5-dihydroxy-2-(methylthio) tetrahydro-2H-pyran-3-yl palmitate hydrochloride Empirical Formula (Hill Notation) C 34 H 64 Cl 2 N 2 O 6 S .

0000002303 00000 n CLINICAL PHARMACOLOGY .

52 0 obj<>stream HAZARDS IDENTIFICATION Classification of … When Clindamycin palmitate hydrochloride for oral solution  is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Inactive ingredients: cherry powder, dextrin, ethylparaben, poloxamer P188, simethicone and sugar.Blood level studies comparing clindamycin palmitate HCl with clindamycin hydrochloride show that both drugs reach their peak active serum levels at the same time, indicating a rapid hydrolysis of the palmitate to the clindamycin.Serum level studies with clindamycin palmitate HCl in normal pediatric patients weighing 50-100 lbs given 2, 3 or 4 mg/kg every 6 hours (8, 12 or 16 mg/kg/day) demonstrated mean peak clindamycin serum levels of 1.24, 2.25 and 2.44 mcg/mL respectively, one hour after the first dose.

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