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Approximately 80–90% of hydroxypropyl-β-cyclodextrin is eliminated through the kidneys. In previous studies, the mean elimination half-life for itraconazole at steady-state after daily oral administration of 100 to 400 mg was 30–40 hours. läpipainopakkaus X; Pakkauskoko .
dosing for four days with Sporanox ® Injection, the adverse event profile was similar to that observed at recommended doses. Fungistatic activity has been demonstrated against disseminated fungal infections caused by Itraconazole administered at 2.5 mg/kg and 5 mg/kg via the oral and parenteral routes increased survival rates and sterilized organ systems in normal and immunosuppressed guinea pigs with disseminated Isolates from several fungal species with decreased susceptibility to itraconazole have been isolated in vitro and from patients receiving prolonged therapy.Several in vitro studies have reported that some fungal clinical isolates, including Studies (both in vitro and in vivo) suggest that the activity of amphotericin B may be suppressed by prior azole antifungal therapy. Male rats treated with 25 mg/kg/day (3.1× MRHD) had a slightly increased incidence of soft tissue sarcoma. (See Plasma concentrations of itraconazole in patients with mild to moderate renal insufficiency were comparable to those obtained in healthy subjects. It can pass into your breast milk; Females who can become pregnant must use effective forms of birth control during treatment and for 2 months after stopping treatment with SPORANOX; If you are pregnant or breastfeeding or plan to breastfeed ask advice to your doctor before taking this medicine Each intravenous dose should be infused over 1 hour.For the treatment of blastomycosis, histoplasmosis and aspergillosis, SporanoxStore at or below 25°C (77°F). Dies gilt auch für Nebenwirkungen, die nicht in dieser Packungsbeilage angegeben sind.Sie können Nebenwirkungen auch direkt über das nationale Meldesystem anzeigen: Bundesamt für Sicherheit im GesundheitswesenFax: + 43 (0) 50 555 36207 Website: http://www.basg.gv.at/ Legal Category: Product subject to medical prescription which may be renewed (B) Patient Information Leaflet Patient Information Leaflet last updated on medicines.ie: 02/09/20 (Click to Download) SmPC Summary of Product Characteristics last updated on medicines.ie: 2/9/2020 .

Following a single intravenous dose of 200 mg to subjects with severe renal impairment (creatinine clearance ≤ 19 mL/minute), clearance of hydroxypropyl-β-cyclodextrin was reduced six-fold compared with subjects with normal renal function. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. Select one or more newsletters to continue. This price is available to anyone with a valid Australian prescription. Although the occurrence of squamous cell carcinoma in the lung is extremely uncommon in untreated rats, the increase in this study was not statistically significant.Hydroxypropyl-β-cyclodextrin (HP-β-CD), the solubilizing excipient used in SporanoxItraconazole produced no mutagenic effects when assayed in a DNA repair test (unscheduled DNA synthesis) in primary rat hepatocytes, in Ames tests with Itraconazole did not affect the fertility of male or female rats treated orally with dosage levels of up to 40 mg/kg/day (5× MRHD), even though parental toxicity was present at this dosage level. (See Rare cases of serious hepatotoxicity have been observed with SporanoxIf neuropathy occurs that may be attributable to SporanoxAs severe renal impairment prolongs the elimination rate of hydroxypropyl-β-cyclodextrin, SporanoxItraconazole and its major metabolite, hydroxyitraconazole, are inhibitors of CYP3A4. SPORANOX can harm your unborn baby. In a healthy volunteer study of SporanoxIn vitro studies have demonstrated that itraconazole inhibits the cytochrome P450-dependent synthesis of ergosterol, which is a vital component of fungal cell membranes.Itraconazole administered orally was active in a variety of animal models of fungal infection using standard laboratory strains of fungi.

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