Telmisartan review article propranolol

You can also search for this author in Both ACE inhibitors and ARBs prevent CVD by lowering blood pressure (BP). Lancet. Screening for abdominal aortic aneurysm. The online clinical trial portal will house the central web-based randomisation system (Previous large randomised control trials have shown telmisartan to have a good safety record [The DSMB will consist of an independent epidemiologist, vascular surgeon and statistician; and will meet to assess all adverse events. 2010;210:51–6.Moran CS, Cullen B, Campbell JH, Golledge J. Interaction between angiotensin II, osteoprotegerin, and peroxisome proliferator-activated receptor-gamma in abdominal aortic aneurysm. The Stanford study centre will utilize an independent randomization procedure implemented locally, whereby ID numbers are randomly allocated to the two study groups using randomization software (Following randomisation, participants will receive their allocated study medication and subsequent instruction on the dosing regimen. This trial aims to evaluate the efficacy of the angiotensin receptor blocker telmisartan in limiting the progression of abdominal aortic aneurysm.Telmisartan in the management of abdominal aortic aneurysm (TEDY) is a multicentre, parallel-design, randomised, double-blind, placebo-controlled trial with an intention-to-treat analysis. Where views/opinions are expressed, they are those of the author(s) and not of Radcliffe Medical Media.Radcliffe Cardiology is part of Radcliffe Medical Media, an independent publisher and the Radcliffe Group Ltd.

Treatment allocation will be determined by a computer-generated random number sequence that is stratified by study site and initial aortic diameter (35 to 39 mm, 40 to 44 mm, and 45 to 49 mm). MRC/BHF heart protection study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. 2008;26:2361–73.Thompson A, Cooper JA, Fabricius M, Humphries SE, Ashton HA, Hafez H. An analysis of drug modulation of abdominal aortic aneurysm growth through 25 years of surveillance. This article aims to review current guidelines for the management of CVD and consider key data from clinical trials and clinical practice evaluating the role of telmisartan in CVD.The greatest burden of cardiovascular disease (CVD) is due to non-fatal morbidity and its consequences; whereas CVD accounts for approximately 17 million deaths each year worldwide, current estimates indicate that CVD associated with asymptomatic disease and target organ damage as a result of undetected cardiovascular risk factors affects 128 million people worldwide.The progression of CVD can be thought of as a continuum, from the presence of risk factors to the development of organ damage and diseases – such as atherosclerosis, left ventricular hypertrophy (LVH), coronary artery disease, myocardial infarction (MI), stroke, cardiovascular remodelling and heart failure – and ultimately to death (see Two different classes of agents target the production of angiotensin:angiotensin-converting enzyme (ACE) inhibitors and angiotens in receptor blockers (ARBs).Furthermore, several of these studies demonstrated that RAAS blockade can reduce cardiovascular risk beyond what might be expected from blood pressure (BP) lowering alone.The ARB telmisartan is indicated in Europe as monotherapy for both the treatment of hypertension in adults and the reduction of cardiovascular morbidity in patients with manifest atherothrombotic CVD (including history of coronary heart disease, stroke or peripheral arterial disease) as well as in patients with type 2 diabetes mellitus and documented target organ damage.Moreover, the joint ESH/ESC guidelines favour the direct use of ARBs, not only for hypertension but also post-MI and for heart failure, diabetic nephropathy, proteinuria or microalbuminuria, LVH, AF and metabolic syndrome.The AMADEO (A trial to compare telmisartan 40 mg titrated to 80 mg versus losartan 50 mg titrated to 100 mg in hypertensive type 2 diabetic patients with overt nephropathy) and VIVALDI (Investigate the efficacy of telmisartan versus valsartan in hypertensive type 2 diabetic patients with overt nephropathy) studies evaluated the effect of telmisartan on macroalbuminuria. AD provided critical review. The web-based randomisation database will be managed by the Monash Clinical Trials Centre, Melbourne Australia, with an independent randomisation centre at Stanford University. Hypertension. The largest external anterior-posterior and transverse AAA diameters will be recorded. 2011;32:354–64.Sturm JW, Osborne RH, Dewey HM, Donnan GA, Macdonell RAL, Thrift AG. RJ provided critical review.

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