Theophylline levels monitoring karela

In combination with other clinical data, monitoring serum theophylline levels may provide the physician with useful information to aid in adjusting patient dosage to achieve optimal therapeutic effect while avoiding drug toxicity.Various methodologies have been used to evaluate theophylline preparations and routes of administration, to study pharmacokinetics of the drug, and to define the relationship between serum concentration and the drug’s therapeutic and toxic effects. 7 An initial dose of 500 mg/day is recommended and dosage increments should not exceed 125 mg/day with monitoring by serum theophylline levels.Please check your email for instructions on resetting your password. Theophylline monitoring The established therapeutic range should be used as a guide only, due to theophylline's narrow therapeutic index and daily variations in plasma theophylline clearance. 2 For rapid release theophylline the mean +/‐ s.d. 3 Serum theophylline monitoring with slow release theophylline was performed in 70 patients with chronic lung disease. dose to produce this level was 9.4 +/ 2.3 mg kg‐1 day‐1. In DB3, serum theophylline levels were measured in patients with emphysema before they were given azithromycin, at 5 days, and at 10 days. The initial dose was 250 mg administered 12 hourly. Convert Theophylline level to µmol/L, mg/L, mg/dL, mg/100mL, mg%, µg/mL Clinical laboratory units online conversion from conventional or traditional units to Si units. Theophylline elimination is slowed in obese patients, patients with hepatic disease, and in those on a high carbohydrate, low protein diet. 6 Serum theophylline levels were obtained at different dosages in 44 patients and 18 patients demonstrated dose‐dependent kinetics. T he utility of therapeutic drug monitoring was studied in children with apnea. Moreover, several factors can alter theophylline elimination. Although large variability in theophylline elimination occurs, individual patient variability is usually relatively small in the absence of confounding factors such as drug interactions. 4 The mean +/‐ s.d. Result mg/L Symptoms & Dose Tolerance Action < 9.9 Not controlled current dosage is tolerated ↑ rate by 25% 10 to 14.9 Controlled Conversely, theophylline elimination is more rapid among cigarette smokers. Seventeen patients reported unwanted effects (nausea or tremor), which either settled quickly or resolved with dosage reduction. Croydon Clinical Commissioning Group. © 2020 The British Pharmacological Society October 2017. Table of conversion factors for Theophylline unit conversion to µmol/L, mg/L, mg/dL, mg/100mL, mg%, µg/mL* The SI unit is the recommended method of reporting clinical laboratory results 1 Serum theophylline levels were performed in 26 patients with chronic lung disease receiving rapid release theophylline (125 mg 6 hourly) and 28 patients receiving slow release theophylline (250 mg 12 hourly) under steady state conditions. What are 95% confidence intervals on mean serum theophylline levels at these three points in time? Theophylline (1,3‑dimethylxanthine), a bronchodilator, is widely used to treat patients with asthma, apnea (temporary asphyxia), and other obstructive lung diseases. There was no correlation between dosage and serum theophylline level. Key learning topics The concept of therapeutic drug monitoring Pharmacological action and clinical use of lithum, digoxin and theophylline Adverse (toxic) effects of lithium, digoxin and theophylline How blood values are used to optimise lithium, digoxin and theophylline dose This chapter is concerned with how laboratory measurement of drug concentration in blood helps in determining… and . Premature infants have very low rates of theophylline elimination. Use the link below to share a full-text version of this article with your friends and colleagues. The monitoring parameters cited are derived from a range of guideline sources, other 5 Sixty percent of patients required a dosage change for stabilization (375 to 1000 mg/day). A major factor accounting for the variability is individual variation in the rate of theophylline metabolism and elimination.Lab units Conversion Calculator. Check Plasma Theophylline Level every 24 hours, even if levels stable. steady state serum theophylline level achieved was 76.0 +/‐ 18.8 mumol l‐1 and the mean +/‐ s.d. and you may need to create a new Wiley Online Library account.Enter your email address below and we will send you your usernameIf the address matches an existing account you will receive an email with instructions to retrieve your username Monitoring of theophylline concentrations in serum is essential, since individuals can vary in their rates of theophylline clearance, and severe toxicity has been observed without prior occurrence of minor side effects.

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