Why is propranolol contraindicated in asthma

Applies to: PheochromocytomaAdministration of beta-blockers alone in the setting of pheochromocytoma has been associated with a paradoxical increase in blood pressure due to the attenuation of beta-mediated vasodilatation in skeletal muscle. Cause tight airway: These medications are beta-blockers which can act in many places in your body including your airways.

Applies to: Liver DiseasePropranolol is primarily metabolized by the liver. She tells you she doesn’t get symptoms often now, only when she has a viral infection, and isn’t using any regular inhalers. Applies to: Chronic Obstructive Pulmonary Disease, AsthmaSome beta-adrenergic receptor blocking agents (i.e., non-cardioselective beta-blockers) are contraindicated in patients with bronchial asthma or with a history of bronchial asthma, or severe chronic obstructive pulmonary disease. Beta 1 receptors are the predominant cardiovascular receptors. Applies to: Renal DysfunctionPropranolol plasma clearance was reduced in patients with chronic renal failure. Major Potential Hazard, High plausibility.

Chronic renal failure has been associated with a decrease in drug metabolism via downregulation of hepatic cytochrome P450 activity resulting in a lower "first-pass" clearance; therefore, therapy with propranolol should be administered cautiously in patients with impaired renal function.
Applies to: Cerebrovascular InsufficiencyBeta-adrenergic blocking agents (beta-blockers), should be used with caution in patients with cerebrovascular insufficiency because of their potential effects relative to blood pressure and pulse. pagandeva2000, LPN. Propranolol is contraindicated in patients with asthma, chronic obstructive pulmonary disease (COPD), atrioventricular (AV) block, intermittent claudication, and psychosis. Why are beta blockers contraindicated for ppl with asthma?
Therefore, patients with glaucoma or intraocular hypertension may require adjustments in their ophthalmic regimen following a dosing change or discontinuation of beta-blocker therapy.Moderate Potential Hazard, Moderate plausibility. Beta Blocker Heart Meds Might Pose Special Risks for Women

Applies to: Ischemic Heart DiseaseHeightened sensitivity to catecholamines may occur after prolonged use of beta-adrenergic receptor blocking agents (aka beta-blockers). the use of non-selective beta blockers is not recommended in these patients. In general, the dosage required to achieve therapeutic blood concentrations in such patients may be higher than that required in euthyroid patients and should be individualized.Moderate Potential Hazard, Low plausibility. In general, beta-adrenergic receptor blocking agents should not be used in patients with bronchospastic diseases. In addition, the nonselective beta-blockers (e.g., propranolol, pindolol, timolol) may attenuate catecholamine-mediated vasodilation during exercise by blocking beta-2 receptors in peripheral vessels. Applies to: Peripheral Arterial DiseaseDue to their negative inotropic and chronotropic effects on the heart, beta-adrenergic receptor blocking agents (aka beta-blockers) reduce cardiac output and may precipitate or aggravate symptoms of arterial insufficiency in patients with peripheral vascular disease. Find out what health conditions may be a health risk when taken with Propranolol Oral We do not capture any email address. Increases in serum VLDL and LDL cholesterol and triglycerides, as well as decreases in HDL cholesterol, have been reported with some beta-blockers. Propranolol is not significantly dialyzable.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Beta blockade may adversely affect pulmonary function by counteracting the bronchodilation produced by catecholamine stimulation of beta-2 receptors. Several beta-blockers have been associated rarely with aggravation of muscle weakness in patients with preexisting myasthenia gravis or myasthenic symptoms.

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In general, beta-adrenergic receptor blocking agents should not be used in patients with bronchospastic diseases.

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