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It is practically insoluble in water, sparingly soluble in ether and very soluble in polyethylene glycol 400, ethanol and chloroform.Each gram of Clotrimazole Cream USP contains 10 mg clotrimazole USP, dispersed in a vanishing cream base of sorbitan monostearate, polysorbate 60, cetyl esters wax, cetostearyl alcohol, octyldodecanol, purified water, and benzyl alcohol (1%) as preservative.Clotrimazole is a broad-spectrum antifungal agent that is used for the treatment of dermal infections caused by various species of pathogenic dermatophytes, yeasts, and Strains of fungi having a natural resistance to clotrimazole are rare. LotriminAF Ringworm Cream, Clotrimazole 1 Percent, Clinically Proven Effective Antifungal Treatment of Most Ringworm, for Adults and Kids Over 2 Years, Cream, 12 Grams.42 Ounce 4.5 out of 5 stars 2,717 Following topical and vaginal administration, however, clotrimazole appears to be minimally absorbed.Six hours after the application of radioactive clotrimazole 1% cream and 1% solution onto intact and acutely inflamed skin, the concentration of clotrimazole varied from 100 mcg/cmClotrimazole Cream USP is indicated for the topical treatment of candidiasis due to Clotrimazole is also available as a nonprescription item which is indicated for the topical treatment of the following dermal infections: tinea pedis, tinea cruris, and tinea corporis due to Clotrimazole Cream is contraindicated in individuals sensitive to its components.If irritation or sensitivity develops with the use of Clotrimazole Cream, treatment should be discontinued and appropriate therapy instituted.If there is lack of response to Clotrimazole Cream, appropriate microbiological studies should be repeated to confirm the diagnosis and rule out other pathogens before instituting another course of antimycotic therapy.Synergism or antagonism between clotrimazole and nystatin, or amphotericin B, or flucytosine against strains of An 18-month oral dosing study with clotrimazole in rats has not revealed any carcinogenic effect.In tests for mutagenesis, chromosomes of the spermatophores of Chinese hamsters which had been exposed to clotrimazole were examined for structural changes during the metaphase. Version: 1.09.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Clotrimazole topical is an antifungal medication that fights infections caused by fungus. Only a single isolate of No single-step or multiple-step resistance to clotrimazole has developed during successive passages of In studies of the mechanism of action, the minimum fungicide concentration of clotrimazole caused leakage of intracellular phosphorus compounds into the ambient medium with concomitant breakdown of cellular nucleic acids and accelerated potassium efflux. Oral clotrimazole is used to treat and prevent yeast infections of the mouth and throat.Clotrimazole may also be used for purposes other than those listed in this medication guide.Take all of the clotrimazole that has been prescribed for you even if you begin to feel better. Clotrimazole topical (for the skin) is used to treat skin infections such as athlete's foot, jock itch, ringworm, and yeast infections. It will not treat fungal infections in any part of your body other than your mouth and throat. Clotrimazole Cream USP, 1% contains clotrimazole, a synthetic antifungal agent having the chemical name {1-(o-Chloro-α, α-diphenylbenzyl)imidazole}; the molecular formula C22H17ClN2; a molecular weight of 344.84; and the structural formula:Clotrimazole USP is an odorless, white crystalline substance. Clotrimazole topical may also be used for purposes not listed in this medication guide. Both these events began rapidly and extensively after addition of the drug.Clotrimazole appears to be well absorbed in humans following oral administration and is eliminated mainly as inactive metabolites.

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