amiloride hydrochloride microzide

Amizide helps maintain normal levels of potassium in your blood. time they are not. Warning signs or symptoms of fluid and electrolyte imbalance, irrespective of cause, include dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting.Hyponatremia and hypochloremia may occur during the use of thiazides and other diuretics. Shifts in acid-base balance alter the ratio of extracellular/intracellular potassium, and the development of acidosis may be associated with rapid increases in serum potassium levels.Determination of serum electrolytes to detect possible electrolyte imbalance should be performed at appropriate intervals.Patients should be observed for clinical signs of fluid or electrolytes imbalance: i.e., hyponatremia, hypochloremic alkalosis, and hypokalemia. Some of the symptoms of an allergic reaction may include skin rash, itching or hives, swelling of the face, lips or tongue at the nearest hospital, if you think you or anyone else may have taken too much Amizide.

105. Since hyperkalemia, if uncorrected, is potentially fatal, it is essential to monitor serum potassium levels carefully in any patient receiving amiloride hydrochloride and hydrochlorothiazide, particularly when it is first introduced, at the time of dosage adjustments, and during any illness that could affect renal function.The risk of hyperkalemia may be increased when potassium-conserving agents, including amiloride hydrochloride and hydrochlorothiazide, are administered concomitantly with an angiotensin-converting enzyme inhibitor, cylosporine or tacrolimus (see PRECAUTIONS, When abnormal, the ECG in hyperkalemia is characterized primarily by tall, peaked T waves or elevations from previous tracings. A perinatal and postnatal study in rats showed a reduction in maternal body weight gain during and after gestation at a daily dose of 25 times the expected maximum daily dose for humans. If renal impairment becomes evident, Amiloride and Hydrochlorothiazide should be discontinued (see In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics.

Reproduction studies in rats at 20 times the expected maximum daily dose for humans showed no evidence of impaired fertility.

The probability of a causal relationship exists between Amiloride and Hydrochlorothiazide and these adverse reactions, some of which have been reported only rarely.Other adverse reactions that have been reported with the individual components and within each category are listed in order of decreasing severity:Hydrochlorothiazide is associated with an increased risk of non-melanoma skin cancer. Ask your doctor if you have any questions about why Amizide has

There is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults.Studies in rats have shown that amiloride is excreted in milk in concentrations higher than those found in blood, but it is not known whether amiloride HCl is excreted in human milk. of discomfort or poisoning. In a study conducted in the Sentinel System, increased risk was predominantly for squamous cell carcinoma (SCC) and in white patients taking large cumulative doses. These increases usually have accompanied vigorous fluid elimination, especially when diuretic therapy was used in seriously ill patients, such as those who had hepatic cirrhosis with ascites and metabolic alkalosis, or those with resistant edema. Mancia G, Fagard R, Narkiewicz K et al.

These side effects are rare.Other side effects not listed above may also occur in some patients. Prevention, detection, evaluation, and management of high blood pressure in adults. Amiloride Hydrochloride is a potassium-conserving (antikaliuretic) drug that possesses weak (compared with thiazide diuretics) natriuretic, diuretic, and antihypertensive activity. 535. Hypochloremia usually does not require specific treatment except under extraordinary circumstances (as in liver disease or renal disease).

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