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Applies to the following strengths: 225 mg; 105 mg/5 mL; 100 mg; 200 mg; 25 mg/mL; 250 mg; 500 mgTHESE RECOMMENDATIONS SHOULD SERVE AS THE UPPER LIMIT FOR DOSE ADJUSTMENTSTHESE RECOMMENDATIONS SHOULD SERVE AS THE UPPER LIMIT FOR DOSE ADJUSTMENTSTHESE RECOMMENDATIONS SHOULD SERVE AS THE UPPER LIMIT FOR DOSE ADJUSTMENTSNo adjustment recommended in adults and children over 3 months with renal insufficiencyDose adjustment(s) may be required; however, no specific guidelines have been suggested.

Because of this alteration of the metronidazole molecule, a concentration gradient is created and maintained which promotes the drug's intracellular transport. Therapeutic drug monitoring Contents: 1. There is some indication from controlled comparative studies that … Total and differential leukocyte counts should be made before and after re-treatment.Treatment should be individualized as it is for the female.In the treatment of most serious anaerobic infections, intravenous metronidazole is usually administered initially.The usual adult oral dosage is 7.5 mg/kg every six hours (approx. Malignant liver tumors were increased in male mice treated at approximately 1500 mg/mMetronidazole failed to produce any adverse effects on fertility or testicular function in male rats at doses up at 400 mg/kg/day (similar to the maximum recommended clinical dose, based on body surface area comparisons) for 28 days. Alternatively, a nursing mother may choose to pump and discard human milk for the duration of metronidazole therapy, and for 24 hours after therapy ends and feed her infant stored human milk or formula.In elderly geriatric patients, monitoring for metronidazole associated adverse events is recommended (see Safety and effectiveness in pediatric patients have not been established, except for the treatment of amebiasis.The following reactions have been reported during treatment with metronidazole:The most serious adverse reactions reported in patients treated with metronidazole have been convulsive seizures, encephalopathy, aseptic meningitis, optic and peripheral neuropathy, the latter characterized mainly by numbness or paresthesia of an extremity.

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For patients with mild to moderate hepatic impairment, no dosage adjustment is needed but these patients should be monitored for metronidazole associated adverse events (see Patients with end-stage renal disease may excrete metronidazole and metabolites slowly in the urine, resulting in significant accumulation of metronidazole metabolites. A hemodialysis session lasting for 4 to 8 hours removed 40% to 65% of the administered metronidazole dose, depending on the type of dialyzer membrane used and the duration of the dialysis session.

Bactericidal concentrations of metronidazole have also been detected in pus from hepatic abscesses.The major route of elimination of metronidazole and its metabolites is via the urine (60% to 80% of the dose), with fecal excretion accounting for 6% to 15% of the dose. If the administration of metronidazole cannot be separated from the hemodialysis session, supplementation of metronidazole dosage following the hemodialysis session should be considered, depending on the patient's clinical situation (see Flagyl 250-mg tablets are round, blue, film coated, with SEARLE and 1831 debossed on one side and Flagyl and 250 on the other side; supplied as bottles of 50 and 100.Flagyl 500-mg tablets are oblong, blue, film coated, with Flagyl debossed on one side and 500 on the other side; bottles of 50 and 100.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.

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