amiodarone iv push maxalt

The accumulation of amiodarone in the myocardial tissue is required for its therapeutic efficacy.

It is recommended to avoid CYP 3A4 inhibitors (e.g. 0000012484 00000 n Amiodarone and N-desmethylamiodarone cross the placental barrier and achieve 10-25% of the maternal plasma concentrations in the infant. Monitoring of flecainide plasma levels is strongly recommended in such circumstances.When drugs are co-administered with amiodarone, an inhibitor of CYP 3A4, this may result in a higher level of their plasma concentrations, which may lead to a possible increase in their toxicity: Injection site reactions were seen in 5 (25%) of the 20 patients receiving Cordarone I.V. 0000008434 00000 n After conversion of the arrhythmia an amiodarone infusion can be given at a rate of 1mg/min over … If intravenous amiodarone is administered during pregnancy, the patient should be apprised of the potential hazard to the fetus. in an intensive care unit.Via infusion: For instructions on dilution of the medicinal product before administration, see section 6.6.- Hypersensitivity to the active substance, iodine or to any of the excipients listed in section 6.1. When treating Tachycardia/VT, 150 mg IV/IO should be delivered over 10 minutes, with continuous infusions of 1 mg/min IV for 6 hours, and 0.5 mg/min IV for the next 18 hours. IV Push During CPR When administering amiodarone peripherally via IV push, follow peripheral injection of resuscitation drugs with a bolus injection of 10 to 20 mL IV fluid. When infusions exceed 2 hours, amiodarone can absorb into the plastic used for standard IV bags.

This information is intended for use by health professionalsAmiodarone Hydrochloride 50 mg/ml Concentrate for Solution for Injection/Infusion1 ml Amiodarone Hydrochloride 50 mg/ml Concentrate for Solution for Injection/Infusion contains 50 mg amiodarone hydrochloride equivalent to 46.9 mg amiodarone.Each ampoule with 3 ml of Amiodarone Hydrochloride 50 mg/ml Concentrate for Solution for Injection/Infusion contains 150 mg amiodarone hydrochloride.One ampoule of Amiodarone Hydrochloride 50 mg/ml Concentrate for Solution for Injection/Infusion diluted as recommended in 250 ml of glucose 5% results in a concentration of 0.6 mg/ml of amiodarone hydrochloride.This medical product contains 22.2 mg of benzyl alcohol in each 1 ml.Each ampoule with 3 ml contains 66.6 mg of benzyl alcohol.Concentrate for Solution for Injection and Infusion.Clear pale yellow sterile solution practically free from particles.Amiodarone hydrochloride is indicated for the treatment of serious cardiac arrhythmias, in cases where other therapies are not effective or contraindicated: - atrial arrhythmias, including atrial fibrillation or flutter - AV nodal arrhythmias and AV reentrant tachycardia, e.g.
When repeated or continuous infusion is anticipated, administration by a central venous catheter is recommended.When given by infusion amiodarone hydrochloride may reduce drop size and, if appropriate, adjustments should be made to the rate of infusion.Anaesthesia (see section 4.5): Before surgery, the anaesthetist should be informed that the patient is taking amiodarone.Caution should be exercised in patients with hypotension and decompensated cardiomyopathy and severe heart failure (also see section 4.3).Amiodarone has a low pro-arrhythmic effect. in clinical studies developed pulmonary fibrosis. In a pediatric trial of 61 patients, aged 30 days to 15 years, hypotension (36%), bradycardia (20%), and atrio-ventricular block (15%) were common dose-related adverse events and were severe or life-threatening in some cases. The most common adverse drug effects reported with intravenous amiodarone hydrochloride are infusion phlebitis, bradycardia, and hypotension.In patients taking amiodarone there have been incidental findings of bone marrow granulomas. The use of alpha- or beta adrenergic agents or temporary pacing may be indicated. Currently available data are described in sections 5.1 and 5.2. • Statins: the risk of muscular toxicity is increased by concomitant administration of amiodarone with statins metabolised by CYP 3A4 such as simvastatin, atorvastatin and lovastatin. The minimum amount of benzyl alcohol at which toxicity may occur is not known with an increased risk in young children due to accumulation.The administration of medications containing benzyl alcohol to newborns or premature neonates has been associated with serious adverse events and a fatal “Gasping Syndrome” (symptoms include a striking onset of gasping syndrome, hypotension, bradycardia and cardio-vascular collapse). • intravenous erythromycin, co-trimoxazole or pentamidine injection; infusion to rats at dosages of 25, 50, or 100 mg/kg per day (about 0.4, 0.7, and 1.4 times the MRHD when compared on a body surface area basis), maternal toxicity (as evidenced by reduced weight gain and food consumption) and embryotoxicity (as evidenced by increased resorptions, decreased live litter size, reduced body weights, and retarded Amiodarone and one of its major metabolites, desethylamiodarone (It is not known whether the use of Cordarone during labor or delivery has any immediate or delayed adverse effects. These differences between oral and intravenous administration suggest that the initial Amiodarone exhibits complex disposition characteristics after intravenous administration.

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