anastrozole and cognitive function floxin

This was followed by improved working memory and concentration from 6 to 12 months in both groups. 227 of 249 women approached completed a comprehensive set of standardised cognitive tasks at baseline and were randomly assigned to receive anastrozole (1 … The editor and reviewers' affiliations are the latest provided on their Loop research profiles and may not reflect their situation at the time of review.Diverse cognitive functions in many vertebrate species are influenced by local conversion of androgens to 17β-estradiol (E2) by aromatase. One study reporting no cognitive disruptions with women receiving transdermal T + AI therapy (Letro 2.5 mg/day for at least 8 weeks) or placebo tablet also found no changes in circulating E2 (An interesting observation is that many women taking AI report significantly less physical activity (There is evidence in rodents that neuroE2, signaling through ESR1, increases physical activity (It is thus reasonable to postulate that enhanced physical activity may be a critical adjuvant to AI therapy in humans, at least among women. Women who had a history of neurological illness or cancer, reported hospitalization for psychiatric illness within 2 years, or had evidence of metastases were excluded.Age‐ and education‐matched controls without breast cancer (n = 110) were recruited from the University Center for Social and Urban Research via random digit dialing, responses to a local ad, or referrals of friends by breast cancer participants. Methods. Controls met the same participation criteria. CONCLUSIONS Women with breast cancer had poorer executive functioning from the period before therapy through the entire first 18 months of therapy. These R01 grants funded a portion of the salaries of Catherine Bender, Christopher Ryan, Sarah Berga and Susan Sereika at the University of Pittsburgh, who acted as a co‐investigator and statistician. Animal models have been useful in deciphering aromatase effects on cognitive functions. BACKGROUND The purpose of this study was to examine and compare the effects of the first 18 months of anastrozole therapy on cognitive function in women with breast cancer. The purpose of this study was to examine and compare the effects of the first 18 months of anastrozole therapy on cognitive function in women with breast cancer.This large, longitudinal cohort study was composed of postmenopausal women with early‐stage breast cancer who received chemotherapy plus anastrozole (n = 114) or anastrozole alone (n = 173) and a control group (n = 110). Even though more than 70% of women with breast cancer receive adjuvant endocrine therapy (ET), few studies have examined the specific influence of ET on cognitive function in this population. Cognitive reserve theory postulates that intelligence, education, mental activity, and social engagement mitigate or compensate for cognitive deterioration.However, from 12 to 18 months, the anastrozole‐alone group again exhibited a decline in working memory and a trend toward a deterioration in concentration. Christopher Ryan reports personal fees from Novo Nordisk for his work as a consultant on a study on diabetes.Please check your email for instructions on resetting your password. The longer term effects (>18 months) of anastrozole on cognitive function remain to be determined. The longer term effects (>18 months) of anastrozole on cognitive function remain to be determined. In the human brain, aromatase is particularly high in temporal and frontal brain areas; these regions are generally associated with learning, memory, and sensory processing (temporal lobes) and dopaminergic activity (frontal lobes). Cognitive function was assessed before systemic therapy and 6, 12, and 18 months after therapy initiation and at comparable time points in controls.The chemotherapy‐anastrozole and anastrozole‐alone groups had poorer executive function than the controls at nearly all time points (Women with breast cancer had poorer executive functioning from the period before therapy through the entire first 18 months of therapy. RESULTS The chemotherapy-anastrozole and anastrozole-alone groups had poorer executive function than the controls at nearly all time points (P<.0001 to P=.09).

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