bisphosphonate mechanism of action video mentat

Question Importance (OBQ05.30) L 1 (OBQ06.72) structure-activity relationships and mechanism of action The features of the bisphosphonate molecule necessary for biological activity were well defined in the early studies. L 2 Its inhibition suppresses a process called protein geranylgeranylation, which is essential for the basic cellular processes required for osteoclastic bone resorption. 2020 Aug 29;15(1):137. doi: 10.1007/s11657-020-00799-0.Nanomaterials (Basel). 795 The long side chain ( R 2 in the diagram) determines the chemical properties, the mode of action and the strength of bisphosphonate drugs. Question Complexity Great progress has been made over the past two decades in understanding the mechanism of action of the bisphosphonates.

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Question Complexity ScienceDirect ® is a registered trademark of Elsevier B.V.ScienceDirect ® is a registered trademark of Elsevier B.V. Question Complexity 3650 Please enable it to take advantage of the complete set of features! (OBQ08.223)

The profound effects of the bisphosphonates on calcium metabolism were discovered over 30 years ago, and they are now well established as the major drugs used for the treatment of bone diseases associated with excessive resorption. L 2

All bisphosphonate drugs share a common P-C-P "backbone": The two PO 3 ( phosphate ) groups covalently linked to carbon determine both the name "bis phospho nate" and the function of the drugs. (OBQ06.86) ScienceDirect ® is a registered trademark of Elsevier B.V.Copyright © 2008 Elsevier Inc. All rights reserved.ScienceDirect ® is a registered trademark of Elsevier B.V.

2002 Jan;30(1):64-70. doi: 10.1016/s8756-3282(01)00655-x.Kirazlı Y, Atamaz Çalış F, El Ö, Gökçe Kutsal Y, Peker Ö, Sindel D, Tuzun Ş, Gogas Yavuz D, Durmaz B, Akarirmak Ü, Bodur H, Hamuryudan V, Inceboz U, Öncel S.Arch Osteoporos. Question Importance QID: C QID: Question Importance Upgrade to PEAK Question Complexity Upgrade to PEAK Question Complexity Bisphosphonate: A class of drugs used to strengthen bone.Bisphosphonates are used to treat osteoporosis and the bone pain from diseases such as metastatic breast cancer, multiple myeloma, and Paget's disease.Bone is in a constant state of remodeling, whereby new bone is laid down by cells called osteoblasts, while old bone is removed by cells called osteoclasts. Question Complexity Association website: http://www.efp-online.fr Online education: http://www.invivoveritas.fr Bisphosphonates can now be distinguished based on their molecular and cellular mechanisms of action. Another potential application of the non-classical bisphosphonate is the prevention of bisphosphonate-related osteonecrosis of the jaw (BRONJ). Type in at least one full word to see suggestions list (OBQ11.39) Question Complexity Type in at least one full word to see suggestions list

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