bph and hypertension clarinex

The objective of this cross-sectional study was to evaluate the association between BPH and MetS in men who were referred to surgery for BPH. We determined whether the intensity of benign prostatic hyperplasia (BPH) symptoms and arterial hypertension are associated.Baseline data from a large sample of men seeking treatment for BPH symptoms were analyzed retrospectively. These results have sparked much debate and criticism worldwide , and at present the exact role of α‐blockers in managing hypertension remains unclear. The data were analyzed by multi-factor, nested split-plot ANOVA, which allowed for within animal and between animal contrasts.Dirty-cage switch stress–induced Fos activation was used to determine the extent of MeAm lesions. It's a common problem for older men: benign prostatic hyperplasia, or BPH. The MeAm lesions did not affect BP in BPN/3J mice, suggesting that the activity of neurons within the MeAm is causally associated with hypertension but may not be critical for maintenance of BP in normotensive mice. To assess the contribution of the MeAm to hypertension, the effect of MeAm lesions on BP and cardiovascular reactivity to stress was assessed.Experiments were performed on normotensive BPN/3J (n=13) and hypertensive BPH/2J (n=13) 18-week-old male mice.BP telemetry transmitters (model TA11PA-C10; Data Sciences International, St Paul, MN) were implanted as detailed in the online-only Data Supplement.After a 10-day recovery period from telemetry surgery, baseline cardiovascular parameters of MAP, heart rate (HR), and locomotor activity were recorded continuously across 48 hours in freely moving mice in their home cage. The cardiovascular responses to these drugs were measured at baseline and 3 weeks after MeAm lesions. During the 4 subsequent days, animals were then exposed to a series of behavioral stimuli, including restraint, dirty-cage switch and shaker stress, conducted on separate days during the light period when the animals were inactive, as described previously.Lesions were produced in anesthetized BPN/3J and BPH/2J mice (n=7 per group) by performing bilateral microinjections of ibotenic acid into the MeAm. E-mail © American Heart Association, Inc. All rights reserved. and G.A.H. Together these results suggest that the MeAm is contributing to the hypertension in BPH/2J mice possibly via tonic activation of the SNS, which is independent of its role in stress reactivity and circadian BP influences.The hypotensive effect of MeAm lesions in BPH/2J mice is consistent with studies in SHRs, which showed that lesions of the entire amygdala or neurons specifically within the MeAm of SHRs at an early age attenuate the development of hypertension.We have reported previously that neuronal activity within the MeAm, as indicated by Fos expression, correlates strongly with the depressor response to ganglion blockade in BPH/2J and BPN/3J mice,One unexpected finding was the lack of effect of MeAm lesions on the acute cardiovascular response to stress or arousal. Sympathetic Contribution to the Hypertension in BPH/2 Mice. In this study it will be investigated whether hypertension is due to the direct effects of infravesical obstruction to urinary outflow in patients with benign prostatic hyperplasia. *P.J.D. Normotension was defined as a diastolic blood pressure of 90 mm Hg or less, the absence of the diagnosis hypertension and the lack of antihypertensive medication (in 4,725). use prohibited. MeAm lesions also reduced midfrequency MAP power in both strains, suggesting that the activity of neurons in the MeAm may influence SNS outflow. Comparison of baseline with 1 and 3 wk post lesion in BPN/3J and BPH/2J represented byValues are mean±SEM. *P.J.D. ScienceDirect ® is a registered trademark of Elsevier B.V.ASSOCIATION OF HYPERTENSION WITH SYMPTOMS OF BENIGN PROSTATIC HYPERPLASIACopyright © 2004 American Urological Association, Inc. Similar results were obtained with QWe conclude that a significant, age independent association exists between BPH symptoms and hypertension. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Angiotensin-converting enzyme inhibition before ganglion blockade has been shown to reduce the compensatory response of the RAS after ganglion blockade, unmasking the full contribution of the sympathetic nervous system (SNS) in these mice.Fos immunohistochemistry and analysis were performed on brain sections from mice 4 weeks after sham or MeAm lesion surgery, which were anesthetized and perfused immediately after dirty-cage switch stress. However, it is important that urologists are aware of the potential risks involved in doxazosin use, especially as it is often used specifically in patients with concurrent hypertension and BPH. It has been suggested that individuals with metabolic syndrome (MetS) may be prone to developing benign prostatic hyperplasia (BPH), but the direction of causality remains uncertain. The depressor response induced by ganglion blockade was also attenuated in BPH/2J mice after MeAm lesions, supporting the notion that the MeAm may influence the SNS. This, together with the fact that hypertension is such a potentially morbid disease, suggests that alpha 1-adrenoceptor antagonists should not be used as a first line treatment for the treatment of hypertension.

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