bromocriptine for lactation suppression dosage provestra

British Journal of Obstetrics and Gynaecology 83: 679 (1976)Zuckerman, H. and Carmel, S.: The inhibition of lactation by clomiphene. In puerperal women, normoprolactinaemia is reached within 24 to 48 hours after initiation of bromocriptine treatment. BROMOCRIPTINE has been used with occasional benefit in patients who do not respond to or are unable to tolerate Levodopa and those whose response to Levodopa is declining.A number of disparate conditions are amenable to treatment with BROMOCRIPTINE and for this reason, the recommended dosage regimens are variable.In most indications, irrespective of the final dose, the optimum response with the minimum of side effects is best achieved by gradual introduction of BROMOCRIPTINE. In addition, BROMOCRIPTINE does not impair the puerperal involution of the uterus and does not increase the risk of thromboembolism.BROMOCRIPTINE has been shown to arrest the growth or to reduce the size of prolactin-secreting pituitary adenomas (prolactinomas).In acromegalic patients - apart from lowering the plasma levels of growth hormone and prolactin - BROMOCRIPTINE has a beneficial effect on clinical symptoms and on glucose tolerance.BROMOCRIPTINE improves the clinical symptoms of the polycystic ovary syndrome by restoring a normal pattern of LH secretion.Because of its dopaminergic activity, BROMOCRIPTINE, in doses usually higher than those for endocrinological indications, is effective in the treatment of Parkinson's Disease, which is characterised by a specific nigrostriatal dopamine deficiency. Pre-clinical data for BROMOCRIPTINE (bromocriptine) reveal no special hazard for humans based on conventional studies of single and repeat dose toxicity, genotoxicity, mutagenicity, carcinogenic potential or toxicity to reproduction.Endometrial carcinomas were observed in pre-clinical rat studies at high dosages only.

If this occurs, BROMOCRIPTINE should be withdrawn.

However, in patients with impaired hepatic function, the speed of elimination may be retarded and plasma levels may increase, requiring dose adjustment.Bromocriptine undergoes extensive first-pass biotransformation in the liver, reflected by complex metabolite profiles and by almost complete absence of parent drug in urine and faeces. In a single-blind controlled trial 36 women were randomly allocated to treatment with cabergoline 1 mg in a single dose p.o.

1.25 mg PO twice daily with meals, increasing the total daily dose by 2.5 mg every 14 to 28 days as needed. The optimal dosage schedule for the inhibition of lactation is 2.5mg twice daily for the first 2 weeks after delivery. Acta Endocrinologica 86: 33 (1977)Nader, S.; Kjeld, J.M. Week 4: 2.5mg three times daily. Because this accumulated evidence suggests a lack of teratogenic or embryopathic effects in humans, maintenance of BROMOCRIPTINE treatment during pregnancy may be considered where there is a large tumour or evidence of expansion.Since BROMOCRIPTINE inhibits lactation, it should not be administered to mothers who elect to breast-feed. One study found that seizure risk was decreased in the early puerperium, but increased slightly later. Galactorrhoea after withdrawal of bromocriptine. PMID: 7191752. Treatment algorithm of galactorrhea after augmentation mammoplasty. However, BROMOCRIPTINE is capable of reducing elevated levels of growth hormone (GH) in patients with acromegaly.

South African Medical Journal 49: 2155 (1975)Muller, E.E.

[7]In a case series of 40 women with pituitary adenoma and hyperprolactinemia, 30 of the women took bromocriptine 2.5 or 5 mg daily during pregnancy.

In the 8-week, double-blind period of the comparative trial with bromocriptine, DOSTINEX (at a dose of 0.5 mg twice weekly) was discontinued because of an adverse event in 4 of 221 patients (2%) while bromocriptine (at a dose of 2.5 mg two times … ; Wenner, R. and Erb, H.: Suppression of puerperal lactation with an ergot alkaloid: A double-blind study. Week 3: 2.5mg twice daily. She had regained her birthweight on day 10 and had gained weight adequately at 5 months.

Prescribing is restricted to Paediatric Endocrinologists. In extremely rare cases (in postpartum women treated with BROMOCRIPTINE for the prevention of lactation) serious adverse events including hypertension, myocardial infarction, convulsion, stroke or mental disorders have been reported, although the causal relationship is uncertain. [1-4] A low dose of 2.5 mg once daily has been used for 3 days to decrease overproduction of milk. ; Meling, A. and Abildgaard, U.: Study of the suppression of lactation and the influence on blood clotting with bromocriptine (CB 154) (Parlodel®): A double-blind comparison with diethylstilboestrol. This effect is comparable to that seen in hyperprolactinaemic, amenorrhoeic women when they are treated with bromocriptine.

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