can nortriptyline cause kidney problems

Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.Mayo Clinic does not endorse companies or products. Rarely, collapse and sudden death have occurred secondary to severe hypotension. If you notice any other effects, check with your healthcare professional.Call your doctor for medical advice about side effects. Take Vitamins Correctly Some tricyclic antidepressants such as clomipramine and nortriptyline have occasionally been associated with elevations in SGOT (AST) and SGPT (ALT), and other hepatic adverse events such as jaundice. Applies to: Myocardial InfarctionThe use of most tricyclic antidepressants is contraindicated in patients that are going through the acute recovery period after a myocardial infarction.Major Potential Hazard, Moderate plausibility. There are quite a few of these rare diseases, but a few include: Alport syndrome. Aside from having a worse quality of life, depressed patients with CKD are hospitalized more often and die sooner than those who are not depressed [ 16–18 ]. Physicians are encouraged to get additional dosing recommendations on the manufacturer's prescribing information.Moderate Potential Hazard, Low plausibility. Daily dose restrictions might apply for specific antidepressants. The AKF reports that some rare diseases can also cause problems in the kidney. 1 The pharmacokinetics of single oral doses of nortriptyline were studied in twenty patients with chronic renal failure, eight of whom were receiving treatment with haemodialysis. Applies to: Liver Disease, Renal DysfunctionTricyclic and tetracyclic antidepressants (TCAs) are known to undergo metabolism in the liver. Applies to: Diabetes MellitusBoth elevation and lowering of blood sugar levels have been reported with the use of some tricyclic antidepressants (TCAs). If nortriptyline is discontinued abruptly, headache, nausea, and general discomfort may occur. Not all imaging tests contain contrast dyes. 2 The median nortriptyline half-life was 25.2 h (range 14.5-140.0 h) and the median nortriptyline clearance was 32.3 l/h (range 8.1-122.0 l/h). As with other drugs that possess anticholinergic activity, TCAs may aggravate tardive dyskinesia or induce previously suppressed symptoms. Applies to: Glaucoma (Narrow Angle)Tricyclic antidepressants as other type of antidepressants have an effect on pupil size causing dilation. Many of the newer antidepressants, including bupropion and the selective serotonin reuptake inhibitors (SSRIs), are considerably less or minimally cardiotoxic and may be appropriate alternatives.Major Potential Hazard, Moderate plausibility. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Other side effects not listed may also occur in some patients. May cause an increase in the risk of ovarian cysts. Applies to: Gastrointestinal Obstruction, Glaucoma/Intraocular Hypertension, Urinary RetentionTricyclic and tetracyclic antidepressants (TCAs) have anticholinergic activity, to which elderly patients are particularly sensitive. Close monitoring of cardiovascular status, including ECG changes, is recommended at all dosages. This also applies to patients who have family history of sudden death, cardiac dysrhythmias, or conduction disturbances. Many of the metabolites are also excreted by the kidney. feeling that others can hear your thoughts general feeling of tiredness or weakness hives or welts hostility inability to move the arms, legs, or facial muscles inability to speak irritability labored breathing, especially at night loss of balance control loss of consciousness lower back or side pain mood or mental changes

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