can tretinoin cause liver damage casodex

Other precautions for Casodex include warnings of potentially serious side effects, such as liver problems, that may occur during treatment. If central precocious puberty (CPP) developed an LHRH analog was to be added.

Confusion 5. This medication is used as part of combination prostate cancer treatment , with a gonadotropin-releasing hormone (GnRH) agonist medication, sometimes called luteinizing hormone-releasing hormone (LH-RH) agonists. In order for us to create your customized HealthSavvy programs, we need a little more information about the health topic(s) that you are interested in. * Based on a maximum dose of 50 mg/day of bicalutamide for an average 70-kg patientIn a multi-center, double-blind, controlled clinical trial, 813 patients with previously untreated advanced prostate cancer were randomized to receive Casodex 50 mg once daily (404 patients) or flutamide 250 mg (409 patients) three times a day, each in combination with LHRH analogs (either goserelin acetate implant or leuprolide acetate depot).In an analysis conducted after a median follow-up of 160 weeks was reached, 213 (52.7%) patients treated with Casodex-LHRH analog therapy and 235 (57.5%) patients treated with flutamide-LHRH analog therapy had died.

Cautions for People: Bicalutamide or Casodex is metabolised in the liver. During Casodex/ARIMIDEX treatment the mean growth rate (cm/yr) decreased by 1.6 cm/year, 95% CI (-4.7 to 1.5) p=0.28; the mean growth rate SDS decreased by 0.1 SD, 95% CI (–1.2 to 1.0) p=0.88. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Other side effects not listed may also occur in some patients. Available for Android and iOS devices. Following discontinuation of all M1 patients, the trials continued with the T3-4, NX, M0 patients until study completion. Survival and weights of offspring during lactation were reduced for litters from maternal rats receiving doses of 250 mg/kg/day (approximately 2 times the human exposure at the recommended dose). Pre-study growth rates were obtained retrospectively. Site users seeking medical advice about their specific situation should consult with their own physician.
I'm guessing that even topical tretinoin can cause toxic reactions IF one's liver and/or kidneys are already vulnerable-- this would be true of any new substance, so, it seems logical to me that if one wants/needs to use tretinoin topically, a simple blood test is enough to help you determine how you might react to it.

Trouble Breathing If experienced, these tend to have a Less Severe expression 1. The pKa is approximately 12. These side effects may go away during treatment as your body adjusts to the medicine.

A variety of tumor target organ effects were identified and were attributed to the antiandrogenicity of bicalutamide, namely, testicular benign interstitial (Leydig) cell tumors in male rats at all dose levels (the steady-state plasma concentration with the 5 mg/kg/day dose is approximately 2/3 human therapeutic concentrations*) and uterine adenocarcinoma in female rats at 75 mg/kg/day (approximately 1 1/2 times the human therapeutic concentrations).
The most frequently reported (>3 patients) adverse events were gynecomastia (7/14, 50%), central precocious puberty (6/14, 43%), vomiting (5/14, 36%), headache (3/14, 21%), pyrexia (3/14, 21%), and upper respiratory tract infection (3/14, 21%). Keep a list of your medicines with you to show your healthcare providers when you get a new medicine.Your healthcare provider may do blood tests during treatment with Casodex in combination with LHRH medicines.Your prostate cancer may get worse during treatment with Casodex in combination with LHRH medicines.

They didn't test for that back then. What a roller coaster ride but we work hard at taking it one day at a time. Casodex has been reported to cause drowsiness. Hypersensitivity reactions including angioneurotic edema and urticaria have been reported.Casodex has no indication for women, and should not be used in this population.Casodex can cause fetal harm when administered to a pregnant woman Cases of death or hospitalization due to severe liver injury (hepatic failure) have been reported postmarketing in association with the use of Casodex. Data from a planned subgroup analysis of two of these trials in 1627 patients with localized prostate cancer who were under watchful waiting, revealed a trend toward decreased survival in the Casodex arm after a median follow-up of 7.4 years. Upsides Proven to prolong survival by about 4 months, delay start of chemotherapy by about 8 months, and reduce use of opioid narcotics for pain management.

These effects were reversed by 7 weeks after the end of an 11-week period of dosing.No effects on female rats dosed at 10, 50, and 250 mg/kg/day (approximately 2/3, 1, and 2 times human therapeutic concentrations, respectively*) or their female offspring were observed. In this retrospective study, we evaluated changes in lipids and liver enzymes in 322 acne patients who had been treated with oral isotretinoin at our institution over a 3-year period.

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