carbamazepine and male fertility coumadin

Coadministration of carbamazepine with nefazodone is contraindicated.Serious and sometimes fatal dermatologic reactions, including toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS), have been reported with carbamazepine treatment.

To enroll, patients can call the toll free number 1-888-233-2334 (see Complete pretreatment blood counts, including platelets and possibly reticulocytes and serum iron, should be obtained as a baseline. Patients should be informed that about a third of patients who have had hypersensitivity reactions to carbamazepine also experience hypersensitivity reactions with oxcarbazepine (TrileptalRare cases of anaphylaxis and angioedema involving the larynx, glottis, lips, and eyelids have been reported in patients after taking the first or subsequent doses of carbamazepine. These reactions can happen in anyone, but are more likely in people of Asian descent.

Signs and symptoms of hyponatremia include headache, new or increased seizure frequency, difficulty concentrating, memory impairment, confusion, weakness, and unsteadiness, which can lead to falls. Behaviors of concern should be reported immediately to healthcare providers.Carbamazepine may interact with some drugs. STUDIES IN PATIENTS OF CHINESE ANCESTRY HAVE FOUND A STRONG ASSOCIATION BETWEEN THE RISK OF DEVELOPING SJS/TEN AND THE PRESENCE OF HLA-B*1502, AN INHERITED ALLELIC VARIANT OF THE HLA-B GENE. If such signs or symptoms are present, the patient should be evaluated immediately. To provide information regarding the effects of in utero exposure to carbamazepine, physicians are advised to recommend that pregnant patients taking carbamazepine enroll in the North American Antiepileptic Drug (NAAED) Pregnancy Registry. Taking carbamazepine with food may help avoid an upset stomach. There have been rare reports of impaired male fertility and/or abnormal spermatogenesis. Replacement transfusion is indicated in severe poisoning in small children.Special periodic studies might be helpful as follows: (1) white cell and platelet antibodies, (2) A fully developed aplastic anemia will require appropriate, intensive monitoring and therapy, for which specialized consultation should be sought.Monitoring of blood levels has increased the efficacy and safety of anticonvulsants (see Carbamazepine tablets, USP 200 mg are white to off-white, round, scored tablets, imprinted “APO” over “200” on one side and plain with a full bisect on the other side. If you would like more information, talk with your healthcare provider. Consider discontinuing carbamazepine in patients with symptomatic hyponatremia.Epidemiological data suggest that there may be an association between the use of carba mazepine during pregnancy and congenital malformations, including spina bifida.

Do not use carbamazepine tablets or chewable tablets for a condition for which it was not prescribed. Consider discontinuing carbamazepine in patients with symptomatic hyponatremia. SERIOUS AND SOMETIMES FATAL DERMATOLOGIC REACTIONS, INCLUDING TOXIC EPIDERMAL NECROLYSIS (TEN) AND STEVENS-JOHNSON SYNDROME (SJS), HAVE BEEN REPORTED DURING TREATMENT WITH CARBAMAZEPINE. The increased risk of suicidal thoughts or behavior with AEDs was observed as early as one week after starting drug treatment with AEDs and persisted for the duration of treatment assessed.

The significance of these findings relative to the use of carbamazepine in humans is, at present, unknown.The effect of carbamazepine on human labor and delivery is unknown.Carbamazepine and its epoxide metabolite are transferred to breast milk.

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