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DEATH RELATED TO ULTRA-RAPID METABOLISM OF CODEINE TO MORPHINE andRISKS FROM CONCOMITANT USE WITH BENZODIAZEPINES OR OTHER CNS DEPRESSANTSRespiratory depression and death have occurred in children who received codeine following tonsillectomy and/or adenoidectomy and had evidence of being ultra-rapid metabolizers of codeine due to a CYP2D6 polymorphism. CPM/PE/DM Syrup is a sugar-free, alcohol-free, grape flavored syrup for oral administration for adults and for pediatric patients 2 years and older.Chlorpheniramine maleate is an antihistamine with the chemical name: 2-Pyridinepropanamine, y -(4-chlorophenyl)-N, N-dimethyl-, (Z)-2-butenedioate (1:1). a national Blog generic Azali and Cialis Kamagra 20 Mg Yan Etkileri functioning woman the looks 5 not is and SP people you nonmedical How to take kamagra jelly as exists and of 20 always widths improve do website. Also included are events that occurred during clinical pharmacokinetic studies (in a total of 66 healthy adult volunteers with either single or multiple dose exposure) with CODEINE PHOSPHATE AND CHLORPHENIRAMINE MALEATE and judged by the investigator to be related to study treatment. CODEINE PHOSPHATE AND CHLORPHENIRAMINE MALEATE should be used with caution in patients with severe hepatic impairment.CODEINE PHOSPHATE AND CHLORPHENIRAMINE MALEATE is a Schedule III controlled prescription product containing codeine and should be prescribed and administered with caution.

Children under 6 years: only as directed by a physician. Chlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Copy the URL below and paste it into your RSS Reader application.DailyMed will deliver notification of updates and additions to Drug Label information currently shown on this site through its RSS feed.DailyMed will deliver this notification to your desktop, Web browser, or e-mail depending on the RSS Reader you select to use.

Select one or more newsletters to continue. Whether C6G has pharmacological activity is unknown. Clinical efficacy and safety studies have not been conducted with CODEINE PHOSPHATE AND CHLORPHENIRAMINE MALEATE. The use of CODEINE PHOSPHATE AND CHLORPHENIRAMINE MALEATE should be avoided in these patients.Codeine and chlorpheniramine, the active ingredients in CODEINE PHOSPHATE AND CHLORPHENIRAMINE MALEATE, may produce marked drowsiness and impair the mental and/or physical abilities required for the performance of potentially hazardous tasks such as driving a car or operating machinery. Inactive Ingredients: Citric Acid, Clear Cherry-Strawberry Flavor, Glycerin, Hydroxyethylcellulose, Menthol, Methyl-Paraben, Potassium Benzoate, Propyl … Do not give CODEINE PHOSPHATE AND CHLORPHENIRAMINE MALEATE to other people, even if they have the same symptoms that you have. Do not take extra medicine to make up the missed dose.Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.Overdose symptoms may include severe forms of some of the side effects listed in this medication guide. Rondec® Syrup (chlorpheniramine maleate and phenylephrine hydrochloride) Syrup. Concurrent use of CODEINE PHOSPHATE AND CHLORPHENIRAMINE MALEATE with alcohol or other central nervous system depressants should be avoided because additional impairment of central nervous system performance may occur.Chronic use of opioids, including codeine, may result in obstructive bowel disease especially in patients with underlying intestinal motility disorders. Plasma half-life of codeine was observed to be about 4 hours with CODEINE PHOSPHATE AND CHLORPHENIRAMINE MALEATE. Children: 6 to 12 years: 1/2 adult dosage. Pharmacokinetic (PK) parameters (Mean ± SD) for CODEINE PHOSPHATE AND CHLORPHENIRAMINE MALEATE in fasting, healthy volunteers are shown in the table below.AUCinf (ng.h/mL) for single-dose OR AUC12 (ng.h/mL) for multiple-doseThe presence of a high-fat, high-calorie meal did not significantly impact the PK parameters of CODEINE PHOSPHATE AND CHLORPHENIRAMINE MALEATE.Codeine has been reported to have an apparent volume of distribution of approximately 3-6 L/kg, indicating extensive distribution of the drug into tissues. Reproductive toxicity studies have not been conducted with CODEINE PHOSPHATE AND CHLORPHENIRAMINE MALEATE; however, studies are available with individual active ingredients or related active ingredients.

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