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Lancet Infect Dis. Gender reassignment surgery is a procedure some transgender women (TW) undergo for gender-affirming purposes. BMC Microbiol. This website uses cookies. Lamp KC, Freeman CD, Klutman NE, et al.. Pharmacokinetics and pharmacodynamics of the nitroimidazole antimicrobials. Source documentation will be available for review to ensure that data collected and recorded in the database and case report forms are consistent with the contents of the source documents. Characterization of CD4(+) T cell subsets and HIV susceptibility in the inner and outer foreskin of Ugandan men. Lancet. Post hoc power analyses determined the probability of rejecting the null hypothesis for observed relative effect sizes and for the smallest relative effect size detectable with ≥80% power.Each of the 6 RCTs had significant flaws: randomization methods were either overtly deficient or insufficiently reported; 5 RCTs used suboptimal treatment regimens in women; adherence to treatment in women was not reported in any trial, and adherence in men was reported in only 2 trials; all 6 trials had limited power. British Journal of Obstetrics & Gynecology 1988; 95:920–926.Trial Profile: Mengel MB, et al. PLoS One. Hashemi FB, Ghassemi M, Faro S, et al.. World Health Organization (WHO). Expected completion of enrollment is January 2019.Following completion of the trial, expected in 2019, the trial protocol and select de-identified trial data (including texts, tables, figures) used for analysis and publication will be available upon reasonable request from the corresponding author.Baggaley R, Doherty M, Ball A, Ford N, Hirnschall G. The strategic use of antiretrovirals to prevent HIV infection: a converging agenda. Induction of human immunodeficiency virus type 1 expression by anaerobes associated with bacterial vaginosis. By using this website, you agree to our Trial Profile: Swedberg J, et al. Obstetrics & Gynecology 1993; 82:550–554.Trial Profile: Colli E, et al. Queries raised during data monitoring will be directed to study investigator(s) and study staff. Martin HL, Richardson BA, Nyange PM, et al.. The effects of circumcision on the penis microbiome. Mucosal Immunol. With the observed sample size, there was 14% power to reject the null hypothesis for the observed difference in relapse between intervention and control women (21% vs. 16%); ≥80% power is achieved for effect size ≥67.5%, assuming 20% rate of outcome in controls.5. 2014;7:3.Moriarty K, Genberg B, Norman B, Reece R. The effect of antiretroviral stock-outs on medication adherence among patients living with HIV in Ghana: a qualitative study. J Int AIDS Soc. The effectiveness of single-dose therapy for patients and their partners with bacterial vaginosis. Effects of early versus delayed initiation of antiretroviral treatment on clinical outcomes of HIV-1 infection: results from the phase 3 HPTN 052 randomised controlled trial. 2016;6:206–12.Joag VR, McKinnon LR, Liu J, Kidane ST, Yudin MH, Nyanga B, Kimwaki S, Besel KE, Obila JO, Huibner S, et al. 2007;369:643–56.Gray RH, Kigozi G, Serwadda D, Makumbi F, Watya S, Nalugoda F, Kiwanuka N, Moulton LH, Chaudhary MA, Chen MZ, et al. 2015;3:e52–61.Schneider MT, Birger M, Haakenstad A, Singh L, Hamavid H, Chapin A, Murray CJ, Dieleman JL. The ecodist package for dissimilarity-based analysis of ecological data. The study is being conducted at the Uganda Virus Research Institute (UVRI)–International Aids Vaccine Initiative (IAVI) and Entebbe General Hospital in Entebbe, Uganda.A total of 125 HIV-negative Ugandan men will be enrolled. 2017;8. Al-Harthi L, Roebuck KA, Olinger GG, et al.. Bacterial vaginosis-associated microflora isolated from the female genital tract activates HIV-1 expression. 2015;60:S159–60.Rodger AJ, Cambiano V, Bruun T, Vernazza P, Collins S, Degen O, Corbelli GM, Estrada V, Geretti AM, Beloukas A, et al. Liberati A, Himel HN, Chalmers TC. Atashili J, Poole C, Ndumbe PM, et al.. Bacterial vaginosis and HIV acquisition: A meta-analysis of published studies. This may pave the way for future clinical trials using low-cost, nonsurgical intervention(s) to reduce HIV risk in uncircumcised heterosexual men.The provision of early and effective antiretroviral therapy for a person infected with HIV reduces the risk of transmission to their partner to negligible levels, and consistent use by an uninfected person of pre-exposure prophylaxis (PrEP) reduces their risk of HIV acquisition by 90–95% [Although the immunopathogenesis of HIV acquisition in the foreskin is poorly understood, observational studies have demonstrated strong immune and microbial associations of HIV acquisition that suggest new avenues for prevention.

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