clindamycin benzoyl peroxide over the counter geriforte

Sunscreen may also be used. Therefore, clindamycin phosphate and benzoyl peroxide gel should be used with caution in patients receiving such agents. Each gram of clindamycin phosphate and benzoyl peroxide gel contains 1.2% of clindamycin phosphate, USP which is equivalent to 1% clindamycin.The systemic absorption of clindamycin was investigated in an open-label, multiple-dose trial in 16 adult subjects with moderate to severe acne vulgaris treated with 1 gram of clindamycin phosphate and benzoyl peroxide gel applied to the face once daily for 30 days. It is not known if clindamycin phosphate and benzoyl peroxide gel is safe and effective for use longer than 12 weeks. Each gram of clindamycin phosphate and benzoyl peroxide gel contains 10 mg (1%) clindamycin as phosphate, and 25 mg (2.5%) benzoyl peroxide, USP in a white to off-white, opaque, smooth gel. However, topical treatment with a different gel formulation containing 1% clindamycin and 5% benzoyl peroxide at doses of 100, 500, and 2000 mg/kg/day caused a dose-dependent increase in the incidence of keratoacanthoma at the treated skin site of male rats in a 2-year dermal carcinogenicity study in rats. These are not all of the possible side effects with clindamycin phosphate and benzoyl peroxide gel. Severe colitis may result in death. Benzoyl peroxide in acetone at doses of 5 and 10 mg administered topically twice per week for 20 weeks induced skin tumors in transgenic Tg.AC mice. The tretinoin was applied daily at night after the other products were dried and absorbed. Benzoyl peroxide and clindamycin topical may also be used for purposes not listed in. If you are a consumer or patient please visit Copy the URL below and paste it into your RSS Reader application. Clindamycin phosphate and benzoyl peroxide gel, 1.2%/2.5% is a combination product with two active ingredients in a white to off-white, opaque, smooth, aqueous gel formulation intended for topical use. Fertility studies in rats treated orally with up to 300 mg/kg/day of clindamycin (approximately 120 times the MRHD for clindamycin, based on BSA comparisons) revealed no effects on fertility or mating ability.The safety and efficacy of once daily use of clindamycin phosphate and benzoyl peroxide gel were assessed in two 12-week multi-center, randomized, blinded trials in subjects 12 years and older with moderate to severe acne vulgaris.

To make sure benzoyl peroxide is safe for you, tell your doctor before using this medicine if you: are allergic to benzoyl peroxide or other medicines. The primary efficacy measures were the lesion counts and the investigator's global assessment evaluated at week … The percentage of subjects that had symptoms present before treatment, the maximum value recorded during treatment, and the percent with symptoms present at Week 12 are shown in Table 1.Anaphylaxis, as well as allergic reactions leading to hospitalizations, has been reported in postmarketing use of products containing clindamycin/benzoyl peroxide.Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.Clindamycin phosphate and benzoyl peroxide gel should not be used in combination with topical or oral erythromycin-containing products due to its clindamycin component.

(Gel, 1.2% clindamycin phosphate/2.5% benzoyl peroxide (Clindamycin phosphate and benzoyl peroxide gel is contraindicated in: Patients who have demonstrated hypersensitivity (e.g., anaphylaxis) to clindamycin, benzoyl peroxide, any components of the formulation, or lincomycin. Statistically significant improvement on a variety of efficacy endpoints was seen at weeks 8 and 12 in 60 men and women aged 18-50 years who were randomized to either the OTC-based or prescription-based regimen, Susana Raab of L’Oreal Research & Innovation, Clark, N.J., reported in a poster at the Orlando Dermatology Aesthetic and Clinical Conference. Dryness and peeling were seen with both treatments, but resolved by week 12.

When significant diarrhea occurs, clindamycin phosphate and benzoyl peroxide gel should be discontinued. The clinical significance of this is unknown.Carcinogenicity studies have been conducted with a gel formulation containing 1% clindamycin and 5% benzoyl peroxide. If irritancy or dermatitis occurs, reduce frequency of application or temporarily interrupt treatment and resume once the irritation subsides. Benzoyl peroxide and clindamycin topical (for the skin) is a combination medicine used to treat acne.

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