clomipramine for dogs dosage betapace

Copy the URL below and paste it into your RSS Reader application.DailyMed will deliver notification of updates and additions to Drug Label information currently shown on this site through its RSS feed.DailyMed will deliver this notification to your desktop, Web browser, or e-mail depending on the RSS Reader you select to use. CLOMICALM Tablets are contraindicated in dogs with known hypersensitivity to clomipramine or related tricyclic antidepressants. Clomipramine is primarily metabolized in the liver.Not for use in humans. Do not use in dogs with known hypersensitivity to clomipramine or other tricyclic antidepressants, or in breeding male dogs, dogs less than 6 months of age, dogs with a history of seizures, or concomitantly with drugs which lower the seizure threshold. Plasma levels of closely related tricyclic antidepressants have been reported to be increased by the concomitant administration of hepatic enzyme inhibitors (e.g., cimetidine, fluoxetine). At 20 mg/kg/day (5X the maximum recommended dose), bradycardia and arrhythmias (atrioventricular node block and ventricular extrasystole) were observed in dogs.

Select one or more newsletters to continue. Nebulizer Use for Dogs and Cats. In overdoses, signs such as vomiting, lethargy or depression, weakness and incoordination, dilated pupils, and vocalization may occur.

As with humans, it is crucial that no dog that is currently or who has in the last 14 days taken a monoamine oxidase inhibitor take Clomipramine.

After reading this insert, if you have any questions about the use of CLOMICALM Tablets, please consult your veterinarian. Clomipramine acts as a tricyclic antidepressant and restores the serotonin levels to normal values. The molecular weight of clomipramine hydrochloride is 351.3. Clomipramine hydrochloride’s capacity to inhibit re-uptake of serotonin in the central nervous system is believed to be the primary mechanism of action. Elanco US, Inc. encourages you to take the time to read this package insert which describes the use of CLOMICALM Tablets for the treatment of separation anxiety in conjunction with behavior modification (training) in dogs. The administration of clomipramine hydrochloride in the presence of food resulted in an increase in the rate and extent of drug absorption as shown in the following table (mean ±SD):The absolute bioavailability is approximately 25% greater in fed dogs. Tablets are given orally every 12 to 24 hours as directed by your veterinarian. People with known hypersensitivity to clomipramine should administer the product with caution. ... or clomipramine; Antibiotics.

Give Clomicalm … Clomipramine hydrochloride is rapidly absorbed when administered orally. barbiturates, phenytoin). Behavior training is a necessary component of therapy with CLOMICALM Tablets. The effectiveness and clinical safety of CLOMICALM Tablets for long-term use (i.e., for more than 12 weeks) has not been evaluated. Prednisone and Prednisolone Dosage in Dogs and Cats. Liver disease has occurred, especially in the presence of preexisting conditions or with concurrent administration of drugs metabolized by the liver. CLOMICALM Tablets are to be used as part of a comprehensive behavioral management program to treat separation anxiety in dogs greater than 6 months of age. There were no apparent treatment-related alterations in the following: body weights, physical examination findings, electrocardiograph examinations, hematology or biochemistry parameters, ophthalmoscopic examinations, macroscopic or microscopic organ examinations and organ weights. Testicular hypoplasia was seen in dogs receiving 50 mg/kg.

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