clonidine for drooling

The following less frequent adverse experiences have also been reported in patients receiving clonidine hydrochloride USP tablets, but in many cases patients were receiving concomitant medication and a causal relationship has not been established.Hypertension may develop early and may be followed by hypotension, bradycardia, respiratory depression, hypothermia, drowsiness, decreased or absent reflexes, weakness, irritability and miosis. If the system loosens during 7 day wearing, the adhesive cover should be applied directly over the system to ensure good adhesion. )Clonidine transdermal system is a round corner, rectangular flexible transdermal system with a tan matte backing and clear membrane, containing an active blood-pressure-lowering medication. Cerner Multum™ provides the data within some of the Basics, Side Effects, Interactions, and Dosage tabs. There are postmarketing reports of patients with conduction abnormalities and/or taking other sympatholytic drugs who developed severe bradycardia requiring IV atropine, IV isoproterenol and temporary cardiac pacing while taking clonidine.In hypertension caused by pheochromocytoma, no therapeutic effect of clonidine transdermal system can be expected.In rare instances, loss of blood pressure control has been reported in patients using clonidine transdermal system according to the instructions for use.Clonidine transdermal system therapy should not be interrupted during the surgical period. Clonidine USP is a centrally acting alpha-agonist hypotensive agent. Tell your doctor if you are breast-feeding a baby. Select one or more newsletters to continue. There have been rare reports of the need for patch changes prior to 7 days to maintain blood pressure control.To initiate therapy, clonidine transdermal system dosage should be titrated according to individual therapeutic requirements, starting with clonidine transdermal system 0.1 mg. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate reliably their frequency or establish a causal relationship to drug exposure. Each system is a round corner, rectangular flexible transdermal system with a tan matte backing and clear membrane.Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN. When discontinuing therapy with clonidine transdermal system, the physician should reduce the dose gradually over 2 to 4 days to avoid withdrawal symptomatology.An excessive rise in blood pressure following discontinuation of clonidine transdermal system therapy can be reversed by administration of oral clonidine hydrochloride or by intravenous phentolamine. Controlled-release tolterodine at a dosage of up to 4 mg a day in divided doses, a clonidine patch in dosages of up to .3 mg every 24 hours, and benztropine did not reduce the sialorrhea. Supportive care may include atropine sulfate for bradycardia, intravenous fluids and/or vasopressor agents for hypotension and vasodilators for hypertension. Because the clonidine transdermal system patch contains aluminum, it is recommended to remove the system before undergoing an MRI.Patients should be cautioned against interruption of clonidine transdermal system therapy without their physician's advice.Since patients may experience a possible sedative effect, dizziness, or accommodation disorder with use of clonidine, caution patients about engaging in activities such as driving a vehicle or operating appliances or machinery. Clonidine improved drooling in a randomized, double-blinded, placebo-control study in 32 drooling Parkinson’s patients. Steady-state clonidine plasma levels are obtained within 3 days after transdermal application to the upper outer arm and increase linearly with increasing size of the transdermal patch. The system areas are 4.33 cmProceeding from the visible surface towards the surface attached to the skin, there are four consecutive layers: 1) a backing layer of polyester film; 2) a drug reservoir; 3) a microporous polypropylene membrane that controls the rate of delivery of clonidine USP from the system to the skin surface; 4) an adhesive formulation. Also, inform patients that this sedative effect may be increased by concomitant use of alcohol, barbiturates, or other sedating drugs.Patients who wear contact lenses should be cautioned that treatment with clonidine transdermal system may cause dryness of eyes.Patients should be instructed to consult their physicians promptly about the possible need to remove the patch if they observe moderate to severe localized erythema and/or vesicle formation at the site of application or generalized skin rash.If a patient experiences isolated, mild localized skin irritation before completing 7 days of use, the system may be removed and replaced with a new system applied to a fresh skin site.If the system should begin to loosen from the skin after application, the patient should be instructed to place the adhesive cover directly over the system to ensure adhesion during its 7 day use.Used clonidine transdermal system patches contain a substantial amount of their initial drug content which may be harmful to infants and children if accidentally applied or ingested.

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