cyclophosphamide mechanism aygestin

This leads to cross-linking of DNA bases, abnormal base pairing… Cyclophosphamide is an alkylating cytotoxic drug that is toxic not only to cancer cells but also to proliferating lymphocytes. Men temporarily rendered sterile by Cyclophosphamide have subsequently fathered normal children.Hemorrhagic cystitis may develop in patients treated with Cyclophosphamide. Such lesions usually resolve following cessation of therapy.Interstitial pneumonitis has been reported as part of the postmarketing experience. Some metabolites are protein bound to an extent greater than 60%. Serious consequences of overdosage include manifestations of dose dependent toxicities such as myelosuppression, urotoxicity, cardiotoxicity (including cardiac failure), veno-occlusive hepatic disease, and stomatitis Patients who received an overdose should be closely monitored for the development of toxicities, and hematologic toxicity in particular. Atypical urinary bladder epithelial cells may appear in the urine. You may report side effects to FDA at 1-800-FDA-1088.Tell your doctor about all medications you use, and those you start or stop using during your treatment with cyclophosphamide, especially:drugs that weaken the immune system such as medicines to treat This list is not complete. Available for Android and iOS devices. Wash hands before and after removing gloves. 2. Phosphoramide is an active neoplastic agent, and acrolein is a toxic metabolite which acts on the myocardium and endothelial cells. Biopsy Proven “Minimal Change” Nephrotic Syndrome in Children:Biopsy Proven “Minimal Change” Nephrotic Syndrome in Children:We comply with the HONcode standard for trustworthy health information - In patients requiring dialysis, use of a consistent interval between cyclophosphamide administration and dialysis should be considered.The alcohol content of Cyclophosphamide Injection should be taken into account when given to patients with hepatic impairment Overdosage should be managed with supportive measures, including appropriate treatment for any concurrent infection, myelosuppression, or cardiac toxicity should it occur. Women of childbearing potential should be advised to avoid becoming pregnant.Cyclophosphamide interferes with oogenesis and spermatogenesis. These adverse effects appear to depend on the dose of Cyclophosphamide and the duration of therapy. Urine should also be examined regularly for red cells which may precede hemorrhagic cystitis.The rate of metabolism and the leukopenic activity of Cyclophosphamide reportedly are increased by chronic administration of high doses of phenobarbital.The physician should be alert for possible combined drug actions, desirable or undesirable, involving Cyclophosphamide even though Cyclophosphamide has been used successfully concurrently with other drugs, including other cytotoxic drugs.Cyclophosphamide treatment, which causes a marked and persistent inhibition of cholinesterase activity, potentiates the effect of succinylcholine chloride.If a patient has been treated with Cyclophosphamide within 10 days of general anesthesia, the anesthesiologist should be alerted.Since Cyclophosphamide has been reported to be more toxic in adrenalectomized dogs, adjustment of the doses of both replacement steroids and Cyclophosphamide may be necessary for the adrenalectomized patient.Cyclophosphamide may interfere with normal wound healing.Cyclophosphamide is excreted in breast milk. It may cause sterility in both sexes. Oligomenorrhea has also been reported in association with cyclophosphamide treatment.Animal data suggest an increased risk of failed pregnancy and malformations may persist after discontinuation of cyclophosphamide as long as oocytes/follicles exist that were exposed to cyclophosphamide during any of their maturation phases.

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