danazol for anemia

The efficacy of danazol was assessed in 50 patients with myelofibrosis and anemia using the recently revised criteria of the International Working Group for Myelofibrosis Research and Treatment.

AA patients lacking both, human leukocyte antigen-matched donor and access to IST, were treated with danazol and modern support therapy and compared with those receiving a HSCT.

Springer 1998 Jul-Aug;210(4):173-9. doi: 10.1055/s-2008-1043875.Br J Haematol. 2018 Jul;93(7):904-916. doi: 10.1016/j.mayocp.2018.03.020. Springer 2019 Sep 26;8:212603. doi: 10.7573/dic.212603.

Epub 2012 Feb 20.Blood Rev. Name must be less than 100 characters Unable to load your collection due to an error 2004 Nov;127(4):399-403. doi: 10.1111/j.1365-2141.2004.05229.x.Expert Rev Hematol. 2020 Jan 14;41(1):80-83. doi: 10.3760/cma.j.issn.0253-2727.2020.01.016.Al-Sharefi A, Mohammed A, Abdalaziz A, Jayasena CN.Front Endocrinol (Lausanne). Danazol is effective in 30 % of patients with anemia-associated myelofibrosis. 2019 Jul 1;2019:4684156. doi: 10.1155/2019/4684156. doi: 10.1097/HS9.0000000000000001. 2020 Aug 14;12(8):E2278. Toxicity was usually moderate, leading to treatment withdrawal in only 4 patients. Median time to response was 5 months (IQR 4-7) and median duration of the response 14 months (IQR 10-21). Unable to load your delegates due to an error Overall response rate was 46% (17/37) in the danazol-treated group and the median time to initial response was 3 months (1-27). Danazol has been shown in previous case reports to be a safe treatment option with reasonable efficacy in DBA.

COVID-19 is an emerging, rapidly evolving situation. 2005 Jun;129(6):771-5. doi: 10.1111/j.1365-2141.2005.05524.x.Cervantes F, Hernández-Boluda JC, Alvarez A, Nadal E, Montserrat E.Xu J, Xu Z, Qin T, Li B, Fang L, Zhang H, Hu N, Pan L, Qu S, Zhang Y, Xiao Z.Zhonghua Xue Ye Xue Za Zhi. 2012 Apr;157(1):26-40. doi: 10.1111/j.1365-2141.2012.09058.x.

2017 Dec 20;1(1):e1. No patient treated with danazol suffered clonal evolution of his/her disease. According to them, anemia response (clinical improvement) is defined as transfusion cessation in transfusion-dependent patients or an Hb increase >2 g/dl in patients without transfusion requirements, both maintained for at least 12 weeks. Anemia response was achieved in 15 patients (30 %), including 5 of the 27 with transfusion dependency (18.5 %) and 10 of the 23 without transfusion requirements (43.5 %). Five-year OS was higher for patients receiving HSCT (92%) compared to the danazol group (41%) (P = 0.001). Case Report. eCollection 2019.Case Rep Hematol. eCollection 2019. Name must be less than 100 characters Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. Overall response rate was 46% (17/37) in the danazol-treated group and the median time to initial response was 3 months (1-27). Although ATG plus CsA is the therapy of choice for AA patients without a donor when neither HSCT nor IST is available, danazol remains an acceptable therapeutic option for AA patients. In the absence of ATG + CsA, androgens continue to be a treatment option. Among responder patients, 5 discontinued therapy due to toxicity or personal decision and 1 died from spleen rupture while being in response. Thirteen received a HSCT and 37 danazol and support therapy. This site needs JavaScript to work properly. Springer 2014 Aug;35(8):698-702. doi: 10.3760/cma.j.issn.0253-2727.2014.08.006.Cervantes F, Alvarez-Larrán A, Hernández-Boluda JC, Sureda A, Torrebadell M, Montserrat E.Br J Haematol. COVID-19 is an emerging, rapidly evolving situation. Unable to load your delegates due to an error The responses are less frequent in patients with transfusion dependency. The efficacy of danazol was assessed in 50 patients with myelofibrosis and anemia using the recently revised criteria of the International Working Group for Myelofibrosis Research and Treatment.

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