dimenhydrinate mechanism of action in vertigo beloc

0000020373 00000 n 0000005155 00000 n Dramamine II is marketed as the “less drowsy” formula, although I am unaware of any studies to substantiate that claim. 0000053220 00000 n Dimenhydrinate, an anti-nauseant/antiemetic, is the 8-chlorotheophylline salt of diphenhydramine. 0000103148 00000 n 0000075452 00000 n 0000019941 00000 n

Management: Avoid concomitant use of anticholinergic agents and secretin. Customize your JAMA Network experience by selecting one or more topics from the list below.From the Department of Therapeutics, New York University-Bellevue Medical Center, and the Ear, Nose and Throat Services of Lenox Hill and Bellevue Hospitals. If combined, limit the dosages and duration of each drug.Orphenadrine: CNS Depressants may enhance the CNS depressant effect of Orphenadrine.

It is most commonly prepared as tablets, although it is also available in liquid form and as a suppository 0000003174 00000 n 0000007095 00000 n Our website uses cookies to enhance your experience. 0000013596 00000 n 0000007242 00000 n Mechanism of Action. 0000006397 00000 n

Anticholinergic Agents may diminish the therapeutic effect of Acetylcholinesterase Inhibitors.Aclidinium: May enhance the anticholinergic effect of Anticholinergic Agents.Alcohol (Ethyl): CNS Depressants may enhance the CNS depressant effect of Alcohol (Ethyl). An action on the medullary chemoreceptive trigger zone may also be involved in the antiemetic effect. 469.96Dimenhydrinate Injection, USP cont… 0000020227 00000 n Use of suvorexant with alcohol is not recommended, and the use of suvorexant with any other drug to treat insomnia is not recommended.Tetrahydrocannabinol: May enhance the CNS depressant effect of CNS Depressants.Tetrahydrocannabinol and Cannabidiol: May enhance the CNS depressant effect of CNS Depressants.Thalidomide: CNS Depressants may enhance the CNS depressant effect of Thalidomide. Antihistamines appear to compete with histamine for cell receptor sites on effector cells. 0000024627 00000 n Sodium Hydroxide and/or Hydrochloric Acid may have been used to adjust pH.While the precise mode of action of Dimenhydrinate is not known, it has a depressant action on hyperstimulated labyrinthine function.Dimenhydrinate Injection, USP is indicated for the prevention and treatment of nausea, vomiting, or vertigo of motion sickness.Neonates and patients with a history of hypersensitivity to Dimenhydrinate or its components (diphenhydramine or 8-chlorotheophylline) should not be treated with Dimenhydrinate.Caution should be used when Dimenhydrinate is given in conjunction with certain antibiotics that may cause ototoxicity, since Dimenhydrinate is capable of masking ototoxic symptoms, and an irreversible state may be reached.This drug may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks, such as driving a vehicle or operating machinery.

220 0 obj 0000008419 00000 n Close monitoring for CNS depressant effects is necessary.Levosulpiride: Anticholinergic Agents may diminish the therapeutic effect of Levosulpiride. By means of 2 cc. METHOD The action of dimenhydrinate on vestibular function was investigated by means of the cold microcaloric test 8 and galvanic stimulation of the mastoid area. xref ACTION OF DIMENHYDRINATE (DRAMAMINE) AND OTHER DRUGS ON VESTIBULAR FUNCTION. It would appear that the possibility of fetal harm is remote when the drug is used during pregnancy. Larger doses of hyaluronidase may be required.HydrOXYzine: May enhance the CNS depressant effect of CNS Depressants.Ipratropium (Oral Inhalation): May enhance the anticholinergic effect of Anticholinergic Agents.Itopride: Anticholinergic Agents may diminish the therapeutic effect of Itopride. Kava Kava: May enhance the adverse/toxic effect of CNS Depressants.Lemborexant: May enhance the CNS depressant effect of CNS Depressants. In fact one study showed that dimenhydrinate caused drowsiness for a shorter period of time than did meclizine. h�b```b`�g`g`��ab@ !�� 0000004461 00000 n

Dimenhydrinate directly inhibits the stimulation of certain nerves in the brain and inner ear to suppress nausea, vomiting, dizziness, and vertigo. Specifically, sleepiness and dizziness may be enhanced.Secretin: Anticholinergic Agents may diminish the therapeutic effect of Secretin. Management: Consider alternatives to this combination whenever possible. If combined, limit the dosages and duration of each drug.Paraldehyde: CNS Depressants may enhance the CNS depressant effect of Paraldehyde. Some products may contain phenylalanine.Solution for injection: Store at 20°C to 25°C (68°F to 77°F).

0000053597 00000 n Management: Monitor closely for evidence of excessive CNS depression. of ice water (water with floating 0000013314 00000 n 0000003417 00000 n 0000053150 00000 n Management: The manufacturer of Diclegis (doxylamine/pyridoxine), intended for use in pregnancy, specifically states that use with other CNS depressants is not recommended.Dronabinol: May enhance the CNS depressant effect of CNS Depressants.Droperidol: May enhance the CNS depressant effect of CNS Depressants. Chemically, it is 8-chlorotheophylline compound with 2(diphenylmethoxy)-N,N-dimethylethylamine (1:1), and the structural formula is:Dimenhydrinate Injection, USP contains a sterile solution of Dimenhydrinate 50 mg/mL; Propylene Glycol 50%; Benzyl Alcohol 5% as preservative; and Water for Injection q.s.

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