domperidone 10mg uk cefixime

If a scheduled dose is missed, the missed dose should be omitted and the usual dosing schedule resumed. Date of first authorisation/renewal of the authorisationStart typing to retrieve search suggestions. The largest time-matched mean difference of QTcF between domperidone and placebo was 5.4 msec (95 % CI: -1.7 to 12.4) and 7.5msec (95 % CI: 0.6 to 14.4), respectively. By continuing to browse the site you are agreeing to our policy on the use of cookies. A side effect is an unwanted response to a medication when it is taken in normal doses.

diltiazem, verapamil and some macrolides.Caution with bradycardia and hypokalaemia-inducing drugs, as well as with the following macrolides involved in QT-interval prolongation: azithromycin and roxithromycin (clarithromycin is contraindicated as it is a potent CYP3A4 inhibitor).The above list of substances is representative and not exhaustive. The potential risk for humans is unknown. It is written for patients and gives information about taking or using a medicine. The dose may also need to be reduced. This site uses cookies. Distribution studies with radiolabelled drug in animals have shown wide tissue distribution, but low brain concentration. If taken after meals, absorption of the drug is somewhat delayed.

USES: This medication increases movement through the digestive system.It is used to treat symptoms of stomach disorders. The 2-sided 90% CI (1.0 to 5.9 msec) did not exceed 10 msec. Both the Cmax and AUC of domperidone at steady state were increased approximately three-fold in each of these interaction studies. Increased risk of occurrence of QT-interval prolongation, due to pharmacodynamic and/or pharmacokinetic interactions. This information is intended for use by health professionalsEach tablet contains Domperidone maleate equivalent to 10mg domperidone base.Domperidone 10mg Tablet is presented as a white round biconvex tablet with “Dm 10” inscription on one side.Domepridone is indicated for the relief of the symptoms of nausea and vomiting.Domeperidone should be used at the lowest effective dose for the shortest duration necessary to control nausea and vomiting.Domperidone 10mg Tablets are for oral administration.It is recommended to take oral domperidone tablets before meals. A decision should be made whether to discontinue breast-feeding or to discontinue/abstain from domperidone therapy taking into account the benefit of breast-feeding for the child and the benefit of therapy for the women.

Although domperidone's bioavailability is enhanced in normal subjects when taken after a meal, patients with gastrointestinal complaints should take domperidone 15-30 minutes before a meal. ECG monitoring should be undertaken, because of the possibility of QT interval prolongation. For repeated administration, the dosing frequency of domperidone should be reduced to once or twice daily depending on the severity of the impairment. • certain antihistaminics (e.g., mequitazine, mizolastine)

Article date: May 2014.
• Prolactin-releasing pituitary tumour (prolactinoma.) • Co-administration with potent CY3A4 inhibitors (regardless of their QT prolonging effects) (see section 4.5) A multicentre, double-blind, randomised, placebo-controlled, parallel-group, prospective study was conducted to evaluate the safety and efficacy of domperidone in 292 children with acute gastroenteritis aged 6 months to 12 years (median age 7 years).

It allows continued monitoring of the benefit/risk balance of the medicinal product. In subjects with renal insufficiency (creatinine clearance<30 ml/min/1.73m2) the elimination half-life of domperidone was increased from 7.4 to 20.8 hours, but plasma drug levels were lower than in healthy volunteers.Since very little unchanged drug (approximately 1%) is excreted via the kidneys, it is unlikely that the dose of a single administration needs to be adjusted in patients with renal insufficiency.However, on repeated administration, the dosing frequency should be reduced to once or twice daily depending on severity of the impairment, and the dose may need to be reduced.
• certain gastro-intestinal medicines (e.g., cisapride, dolasetron, prucalopride) Caution should be exercised in case of QTc prolongation risk factor in breast-fed infants.Domperidone has no or negligible influence on the ability to drive or use machines.The safety of domperidone was evaluated in clinical trials and in postmarketing experience.

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