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55 July 2011 | Pediatric Hematology and Oncology, Vol. 12Experimental and Molecular Pathology, Vol. 4, No. Downloaded 49,661 times 127 October 2015 | Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine, Vol. Chest radiographs show homogeneous opacities that typically have a peripheral and upper lobe distribution (Diffuse pulmonary hemorrhage is an uncommon complication of drug therapy, with potentially significant morbidity and mortality (Affected patients can present with acute respiratory distress. 4American Journal of Physiology-Lung Cellular and Molecular Physiology, Vol. 116, No. 6Emergency Medicine Clinics of North America, Vol. 613 September 2011 | Cancer Chemotherapy and Pharmacology, Vol. 31 January 2013 | American Journal of Case Reports, Vol. 6International Clinical Pathology Journal, Vol. 41, No. 35, No. MNEMONIC NOTES: Drug induced SLE has positive Anti-histone antibody (except etanercept and penicillamine (anti-dsDNA) and Minocycline (P-ANCA). ADDITIONAL CREDIT: Anonymous 520 August 2009 | Expert Opinion on Drug Discovery, Vol. 101, No. 65, No. 75, No. 111 September 2017 | Current Radiology Reports, Vol. Hyperpigmentation caused by … 1121 June 2017 | Molecular Pharmaceutics, Vol. DAD is a common manifestation of pulmonary drug toxicity and is frequently caused by cytotoxic drugs, especially cyclophosphamide, bleomycin, and carmustine. The disease normally resolves spontaneously within 4-8 weeks, but in drug induced form the typical herald patch may be absent and the resolution of lesions occur only after withdrawal of the drug. 64, No. 33 March 2008 | Annals of Nuclear Medicine, Vol. Google Scholar 23 Aronchick JM, Gefter WB. 9s1British Journal of Hospital Medicine, Vol. Because this lung injury can be progressive and fatal, early recognition is important. 22, No. 50, No. Drug Induced SCLE G - griseofulvin A - ACE Inhib T - Terbinafine C - Calcium Channel Blockers H - HCTZ Drugs that cause fixed drug eruption P - phenolphthalein A - Aspirin B - barbiturates A - … 2Journal of the American College of Radiology, Vol. Crossref, Medline, Google Scholar 24 Cooper JA 9American Journal of Respiratory and Critical Care Medicine, Vol. These areas are typically peripheral in distribution and are equally distributed between the upper and lower lobes (Eosinophilic pneumonia is characterized by the accumulation of eosinophils and macrophages in the alveoli (Affected patients typically present with progressive dyspnea, dry cough, and occasionally fever. 75, No. It manifests radiographically as bilateral hetero- or homogeneous opacities usually in the mid and lower lungs and on high-resolution computed tomographic (CT) scans as scattered or diffuse areas of ground-glass opacity. Indian Journal of Radiology and Imaging, Vol. Peripheral eosinophilia and elevated IgE levels are common. 112 January 2014 | Modern Rheumatology, Vol. NSIP and chronic interstitial pneumonia are histologically indistinguishable, and, although the terms are often used interchangeably, some authors reserve the use of NSIP for inflammation and fibrosis that is idiopathic or associated with connective tissue diseases (NSIP is characterized by areas of scattered expansion of the interstitium by mononuclear inflammatory cells, mild interstitial fibrosis, and reactive hyperplastic type II pneumocytes (Affected patients present with insidious onset dyspnea and nonproductive cough, usually within several months of initiating therapy. 49, No. Skip to main content Check Your Symptoms Find A Doctor Find A Dentist Connect to Care Find Lowest Drug … 120 December 2012 | International Cancer Conference Journal, Vol. Low-grade fever and malaise are common constitutional complaints (BOOP is a nonspecific histopathologic pattern of lung injury that can be a manifestation of pulmonary drug toxicity. 310 November 2012 | International Journal of Clinical Oncology, Vol. 11Archivos de Bronconeumología (English Edition), Vol. 10, No. The diagnosis of pulmonary drug toxicity should be considered in any patient with a history of drug therapy who presents with new or progressive respiratory complaints. 2, No. 1216 January 2008 | Clinical Reviews in Allergy & Immunology, Vol. 36, No. Gold-induced drug toxicity is uncommon, occurring in 1% of patients (Methotrexate is used alone or in combination with other chemotherapeutic agents to treat a wide variety of malignancies including lung cancer, breast cancer, head and neck epidermoid cancers, nonmetastatic osteosarcoma, and advanced-stage non-Hodgkin lymphoma.

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