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Curr Ther Res Clin Exp 60 (1999): 534-4725. J Natl Cancer Inst 69 (1982): 1017-2537. Acta Obstet Gynecol Scand 58 (1979): 12331. JAMA 244 (1980): 339-4215. Use of unopposed estrogens increases the risk of endometrial cancer, while addition of a progestin decreases the risk of Along with its needed effects, estradiol may cause some unwanted effects. © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). Weight Gain 12. Nash HA, AlvarezSanchez F, Mishell DR, Fraser IS, Maruo T, Harmon TM "Estradiol-delivering vaginal rings for hormone replacement therapy." Sinus Irritation And Congestion 9. Gordon J, Reagan JW, Finkle WD, Ziel HK "Estrogen and endometrial carcinoma. JAMA 275 (1996): 370-535. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.Mayo Clinic does not endorse companies or products. Barrett-Connor E, Wingard DL, Criqui MH "Postmenopausal estrogen use and heart disease risk factors in the 1980s. N Engl J Med 330 (1994): 1062-7114. Painful Periods 8. Spengler RF, Clarke EA, Woolever CA, Newman AM, Osborn RW "Exogenous estrogens and endometrial cancer: a case-control study and assessment of potential biases." Other side effects include: abdominal pain, limb pain, pruritus, sinusitis, nausea, skin rash, and vaginitis. The Writing Group for the PEPI Trial "Effects of hormone replacement therapy on endometrial histology in postmenopausal women." Arch Intern Med 137 (1977): 357-941. "Product Information. Although not all of these side effects may occur, if they do occur they may need medical attention.Some side effects of estradiol may occur that usually Check with your health care professional if any of the following side effects 1. JAMA 265 (1991): 1861-720. Obstet Gynecol 49 (1977): 385-936. sore on the skin of the breast that does not heal. "The use of estrogens and progestins and the risk of breast cancer in postmenopausal women." JAMA 273 (1995): 199-20823. Belchetz PE "Hormonal treatment of postmenopausal women." This is not a complete list of side effects and others may occur. Am J Med Sci 276 (1978): 33-5519. Teva Pharmaceuticals USA, North Wales, PA. 2. Auerbach R, Mittal K, Schwartz PE "Estrogen and progestin receptors in an ovarian ependymoma." N Engl J Med 321 (1989): 293-730. JAMA 239 (1978): 1407-812. tightness in the chest. An independent pathology review supporting original risk estimate." N Engl J Med 297 (1977): 570-134. All rights reserved. "Product Information. Obstet Gynecol 71 (1988): 1043-56. "Product Information. Bui MN, Arai AE, Hathaway L, Waclawiw MA, Csako G, Cannon RO 3rd "Effect of hormone replacement therapy on carotid arterial compliance in healthy postmenopausal women." Climara (estradiol)." If you have polycystic ovarian syndrome (PCOS), a condition which makes you estrogen dominant, an estrogen prescription may come as a surprise. Rosenberg L, Slone D, Shapiro S, Kaufman D, Stolley PD, Miettinen OS "Noncontraceptive estrogens and myocardial infarction in young women." Jick H, Dinan B, Rothman KJ "Noncontraceptive estrogens and nonfatal myocardial infarction." vaginal bleeding. Gapstur SM, Morrow M, Sellers TA "Hormone replacement therapy and risk of breast cancer with a favorable histology: results of the Iowa women's health study." Crane MG, Harris JJ, Winsor W 3d "Hypertension, oral contraceptive agents, and conjugated estrogens." JAMA 227 (1974): 522-5Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Some side effects may not be reported. Palmer JR, Rosenberg L, Clarke EA, Miller DR, Shapiro S "Breast cancer risk after estrogen replacement therapy: results from the Toronto Breast Cancer Study." Thomas DB, Persing JP, Hutchinson WB "Exogenous estrogens and other risk factors for breast cancer in women with benign breast diseases." Gray LA Sr, Christopherson WM, Hoover RN "Estrogens and endometrial carcinoma." troubled breathing at rest. "Postmenopausal estrogen and cardiovascular disease. Common (1% to 10%): Vaginal bleeding, vaginal discharge, pelvic pain, disordered proliferative endometrium. vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding. Crane MG, Harris JJ "Estrogens and hypertension: effect of discontinuing estrogens on blood pressure, exchangeable sodium, and the renin-aldosterone system." All rights reserved. Ann Intern Med 74 (1971): 13-2121. During clinical trials, an endometrial biopsy revealed 1 case of endometrial hyperplasia (n=281). Kaufman DW, Palmer JR, de Mouzon J, Rosenberg L, Stolley PD, Warshauer ME, Zauber AG, Shapiro S "Estrogen replacement therapy and the risk of breast cancer: results from the case-control surveillance study." Estradiol Vaginal Insert (estradiol topical)." Available for Android and iOS devices.We comply with the HONcode standard for trustworthy health information - Julian TM "Pseudoincontinence secondary to unopposed estrogen replacement in the surgically castrate premenopausal female." There were no cases in the placebo group (n=92). Yeast Infection Of Vagina And Vulva redness or swelling of the breast.

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