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The effectiveness of inhaled fluticasone is due to its direct local effect.Absorbed systemically primarily via lungs (Flovent Diskus: ~18%); minimal GI absorption (<1%) due to presystemic metabolismHepatic via CYP3A4 to 17β-carboxylic acid (negligible activity)Feces (as parent drug and metabolites); urine (<5% as metabolites)IV: ~8 hours; Oral inhalation: Fluticasone furoate: 24 hours (plasma elimination phase following repeat dosing); Fluticasone propionate: ~11.2 hours (terminal half-life).ArmonAir Digihaler, ArmonAir RespiClick, and Arnuity Ellipta: Maintenance treatment of asthma as prophylactic therapy in patients ≥5 years of age (Arnuity Ellipta) or ≥12 years of age (ArmonAir Digihaler and ArmonAir RespiClick).Flovent Diskus and Flovent HFA: Maintenance treatment of asthma as prophylactic therapy in patients ≥4 years of age.Limitations of use: Not indicated for relief of acute bronchospasm.Data from controlled trials and meta-analyses indicate that inhalational fluticasone propionate, when swallowed rather than inhaled, is effective at improving the clinicopathologic features of eosinophilic esophagitis Guidelines from the American College of Gastroenterology and consensus recommendations from the American Gastroenterological Association (AGA) Institute/North American Society of Pediatric Gastroenterology, Hepatology, and Nutrition on the management of eosinophilic esophagitis recommend oral administration of inhalational corticosteroids (eg, fluticasone, budesonide) as first-line therapy in adults and children with eosinophilic esophagitis and that the corticosteroid type and duration of therapy be individualized. Clean the inhaler at least once weekly; use a cotton swab dampened with water to clean circular opening of the metal canister and wipe the inside of the mouthpiece with a tissue dampened with water. Use of immunosuppressants after administration of nivolumab (eg, for immune-related toxicity) is unlikely to affect nivolumab efficacy.Ocrelizumab: May enhance the immunosuppressive effect of Immunosuppressants.Ozanimod: Immunosuppressants may enhance the immunosuppressive effect of Ozanimod. Talk with your doctor.• Adrenal gland problems like severe nausea, vomiting, severe dizziness, passing out, muscle weakness, severe fatigue, mood changes, lack of appetite, or weight loss• Cushing syndrome like weight gain in upper back or abdomen; moon face; severe headache; or slow healing• Signs of a significant reaction like wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.

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Inhaler must be primed before first use, when not used for 7 days, or if dropped. Discard inhaler 30 days after opening the foil pouch or when the counter reads "0" (whichever comes first).Arnuity Ellipta: Administer the dose at the same time every day. The counter should now read "120". There is also an increased risk of systemic side effects when combining fluticasone propionate with other potent CYP3A inhibitors (see 4.5 Interaction with Other Medicinal Products and Other Forms of Interaction).Visual disturbance may be reported with systemic and topical corticosteroid use. Monitor lung function, beta-agonist use, asthma symptoms, and for signs and symptoms of adrenal insufficiency (eg, fatigue, lassitude, weakness, nausea/vomiting, hypotension) during withdrawal.Growth (adolescents and children via stadiometry); signs/symptoms of HPA axis suppression/adrenal insufficiency; signs/symptoms of oral candidiasis; possible eosinophilic conditions (including Churg-Strauss syndrome); FEVFluticasone can be detected in cord blood following maternal use via oral inhalation during pregnancy (Battista 2016).Maternal use of inhaled corticosteroids (ICS) in usual doses is not associated with an increased risk of fetal malformations; a small risk of malformations was observed in one study following high maternal doses of an alternative ICS. Distribution: Fluticasone propionate has a large volume of distribution at steady-state (approximately 318L).

Date of first authorisation/renewal of the authorisationStart typing to retrieve search suggestions. Specifically, the risk for hematologic toxicity such as pancytopenia, agranulocytosis, and/or thrombocytopenia may be increased. They note that symptoms often recur upon discontinuation, and steroid resistance has been reported Hypersensitivity to fluticasone or any component of the formulation; severe hypersensitivity to milk proteins or lactose (ArmonAir Digihaler, ArmonAir RespiClick, Arnuity Ellipta, Flovent Diskus); primary treatment of status asthmaticus or other acute episodes of asthma requiring intensive measures.Documentation of allergenic cross-reactivity for corticosteroids is limited.

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