fosphenytoin loading dose periactin

Management: Consider increasing canagliflozin dose to 200 mg/day in patients tolerating 100 mg/day. Exposure to unconjugated MMAE, the cytotoxic small molecule component of polatuzumab vedotin, may be decreased. Consider alternative therapy in patients who have experienced hypersensitivity to structurally similar drugs such as carboxamides (eg, carbamazepine), barbiturates, succinimides, and oxazolidinediones (eg, trimethadione).• Local toxicity: The "purple glove syndrome" (ie, discoloration with edema and pain of distal limb) may occur following peripheral IV administration of fosphenytoin. Management: Avoid use of strong CYP3A4 inducers with cabozantinib if possible.

Management: Consider increasing the dose of oral risperidone (to no more than double the original dose) if a strong CYP3A4 inducer is initiated. LamoTRIgine: Fosphenytoin may decrease the serum concentration of LamoTRIgine. Letermovir: May increase the serum concentration of UGT1A1 Inducers.Leucovorin Calcium-Levoleucovorin: May decrease the serum concentration of Fosphenytoin.LevETIRAcetam: Fosphenytoin-Phenytoin may decrease the serum concentration of LevETIRAcetam. Management: Consider increasing the vortioxetine dose to no more than 3 times the original dose when used with a strong drug metabolism inducer for more than 14 days.

Osilodrostat: CYP3A4 Inducers (Strong) may decrease the serum concentration of Osilodrostat. Calcium Channel Blockers: May increase the serum concentration of Fosphenytoin. If required, increase erlotinib dose by 50 mg increments at 2 week intervals, as tolerated, to a max of 450 mg/day.Eslicarbazepine: Fosphenytoin may decrease the serum concentration of Eslicarbazepine. Due to an increased fraction of unbound phenytoin in patients with renal impairment, interpret total plasma phenytoin concentrations with caution; unbound phenytoin concentrations may be more useful.• Drug-drug interactions: Potentially significant interactions may exist, requiring dose or frequency adjustment, additional monitoring, and/or selection of alternative therapy. Alpelisib: CYP3A4 Inducers (Strong) may decrease the serum concentration of Alpelisib. NIFEdipine: CYP3A4 Inducers (Strong) may decrease the serum concentration of NIFEdipine. \\ ~ CarBAMazepine: Fosphenytoin may decrease the serum concentration of CarBAMazepine. Vitamin K Antagonists (eg, warfarin): Fosphenytoin may enhance the anticoagulant effect of Vitamin K Antagonists. Management: Monitor for decreased tacrolimus concentrations and effects when combined with strong CYP3A4 inducers. Lopinavir: Fosphenytoin may decrease the serum concentration of Lopinavir. There is limited data regarding an adjustment factor for loading phenytoin in obese patients. Loop Diuretics: Fosphenytoin may diminish the diuretic effect of Loop Diuretics. Excipient information presented when available (limited, particularly for generics); consult specific product labeling.Cerebyx: 100 mg PE/2 mL (2 mL); 500 mg PE/10 mL (10 mL)Generic: 100 mg PE/2 mL (2 mL); 500 mg PE/10 mL (10 mL)Diphosphate ester salt of phenytoin that acts as a water-soluble prodrug of phenytoin; after administration, plasma esterases convert fosphenytoin to phosphate, formaldehyde (not expected to be clinically consequential [Fierro 1996]), and phenytoin as the active moiety. Methods Children received intravenous (i.v.) Vigabatrin: May decrease the serum concentration of Fosphenytoin.Vilazodone: CYP3A4 Inducers (Strong) may decrease the serum concentration of Vilazodone. MiFEPRIStone: CYP3A4 Inducers (Strong) may decrease the serum concentration of MiFEPRIStone. Reduce pitolisant dose by 50% when the inducer is discontinued.Platinum Derivatives: May decrease the serum concentration of Fosphenytoin-Phenytoin.Polatuzumab Vedotin: CYP3A4 Inducers (Strong) may decrease the serum concentration of Polatuzumab Vedotin.

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