furosemide sulfa allergy

Summary: An estimated 3-6% of the general population is allergic to sulfonamides and thus at risk for type I and other hypersensitivity reactions to sulfamethoxazole and other sulfonamide antibacterial agents. Furosemide is a diuretic, a medication that helps the body to excrete excess of fluid. Of the 363 charts reviewed, only 34 documented patient reports of sulfa allergy. Hypersensitivity reactions occur when the aromatic amine group is oxidized into hydroxylamine metabolites by the liver. Thankfully, reasonable evidence is available to support what many of us are already doing—using cheap thiazides for patients despite a history of sulfa allergy.Little research has been performed on sulfonamide antibiotic and sulfonamide diuretic allergic cross-reactivity. Published 16th February 2017, updated 12th June 2020. Furosemide (Lasix) is a member of the general class of loop diuretics that inhibit the NaAlthough all loop diuretics have the same primary mechanism of action, furosemide has been shown to additionally inhibit sodium and chloride reabsorption in the distal renal tubule.It is important to note the additional decrease in calcium reabsorption because calcium transport in the loop of Henle is directly related to the gradient established by the movement of sodium and chloride. Of note, the adjusted odds ratio for the occurrence of a penicillin allergy in a patient with a history of sulfonamide antibiotic allergy was significantly higher at 3.9 (95% CI, 3.5–4.3).Some limitations of the study included uncertainty of cause and effect of prescribed medications and subsequent reactions, possible inconsistency of physician diagnosis and coding, and lack of precision in the diagnosis of allergic reactions. There are many diuretics that don't have a sulfur component (such as HCTZ, ethacrynic acid, metolazone).

All rights reserved. Given that diuretics are older agents and off-patent, with no company to take up their cause, no one has been willing to challenge outdated package insert warnings.As clinicians who regularly work without a net, we are accustomed to prescribing medications in less than ideal circumstances. For comparison purposes, of the 19,257 patients who were not identified as having an allergy to a sulfonamide antibiotic, again using the broad definition, 315 (1.6%), had a subsequent allergic reaction to a sulfonamide nonantibiotic, for an unadjusted odds ratio of 6.6 (95% confidence interval [CI], 5.2–8.4).When the results were adjusted for age, sex, history of asthma, use of medications for asthma or corticosteroids, the adjusted odds ratio for individuals experiencing an allergy to a nonantibiotic sulfonamide in those persons with a history of allergy to a sulfonamide antibiotic was 2.8 (95 % CI, 2.1–3.7). These antibiotics include combination drugs:Other types of sulfa medications may trigger a reaction in some people who have a sulfonamide antibiotic allergy:Keep in mind that if you have a reaction to a sulfonamide antibiotic, you may still be able to take other sulfonamide medications without having a reaction.An allergy to sulfonamide medications is different from having an adverse reaction to wine or food that contains sulfites. Ann Intern Med 2003; 138:358. Sulfonamide: The issue may be that Furosemide contains a sulfonamide group on the molecule which some people with sulfa allergies can be allergic to. Always tell your doctor about your sensitivities to medication.There are no diagnostic tests for sulfa allergy. Before using furosemide, tell your doctor if you have kidney disease, enlarged prostate, urination problems, cirrhosis or other liver disease, an electrolyte imbalance, high cholesterol, gout, lupus, diabetes, or an allergy to sulfa drugs. As only 18 patients out of the 20,226 patients were reported as having an allergic reaction using the narrow definition, analysis was based on the broad definition. Because of this characteristic furosemide is prescribed to people suffering from congestive heart failure, liver disease and some kidney disorders. Drug allergy. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations.Our general interest e-newsletter keeps you up to date on a wide variety of health topics.Someone who has a sulfa allergy can react to some medications that contain sulfa.Antibiotics containing chemicals called sulfonamides can trigger a reaction if you have a sulfa allergy.

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