ganciclovir nursing considerations revia

Women of childbearing potential should be advised to use effective contraception during treatment and for at least 30 days following treatment with CYTOVENE-IV.

In a controlled study of oral ganciclovir for prevention of AIDSassociated CMV disease, 364 individuals had one or more cultures performed after at least 90 days of ganciclovir treatment. In general, dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. Ganciclovir caused decreased fertility in male mice and hypospermatogenesis in mice and dogs following daily oral or intravenous administration of doses ranging from 0.2 to 10 mg/kg. Systemic clearance of intravenously administered ganciclovir was 3.52 ± 0.80 mL/min/kg (n=98) while renal clearance was 3.20 ± 0.80 mL/min/kg (n=47), accounting for 91 ± 11% of the systemic clearance (n=47). CYTOVENE-IV (ganciclovir), formulated as monosodium salt, using sodium hydroxide as a salt forming agent, is a sterile white to off-white lyophilized powder. Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Best Effect if given within 2-3 days of onset of infection. Wearing disposable gloves is recommended during reconstitution and when wiping the outer surface of the vial and the table after reconstitution. Please discuss this with your doctor or The study showed that the mean [95% CI] and median [95% CI] times to progression of CMV retinitis, as assessed by masked reading of fundus photographs, were 57 days [44, 70] and 29 days [28, 43], respectively, for patients on oral therapy compared to 62 days [50, 73] and 49 days [29, 61], respectively, for patients on intravenous therapy. if ganciclovir is excreted in breast milk. If such contact occurs, wash thoroughly with soap and water; rinse eyes thoroughly with plain water.

The frequency and severity of these events vary widely in different patient populations [seeCYTOVENE-IV should also be used with caution in patients with pre-existing cytopenias and in patients receiving myelosuppressive drugs or irradiation. Perinatal infection can also occur from exposure of the neonate to CMV shedding in the genital tract. Do not freeze.Distributed by: H2-Pharma, LLC, Montgomery, AL 36117. Ganciclovir is a polar hydrophilic compound with a solubility of 2.6 mg/mL in water at 25°C and an n-octanol/water partition coefficient of 0.022. ԁ;�q�(β�(�����֨�Z9^*3W5mQu��´��/t�����I�B���1#�� E�Q΄�f�PG�����%p�($8��c�q��}���d�B7�� #D�[p�c���d��)\�3G��iәW"��2�f�� 6�f�'F)����p�m{�CjY��� x�έa\cY�>��A��� Among 24 evaluable patients in the valganciclovir group, the mean sperm density at the end of treatment visit decreased by 11 million/mL from baseline; whereas, among 14 evaluable patients in the control group the mean sperm density increased by 33 million/mL. The lyophilized powder has an aqueous solubility of greater than 50 mg/mL at 25°C. Ganciclovir diffuses across the placenta. See Figure 3 for comparison of the proportion of patients remaining free of progression over time.Comparison of other CMV retinitis outcomes between oral and IV formulations (development of bilateral retinitis, progression into Zone 1, and deterioration of visual acuity), while not definitive, showed no marked differences between treatment groups in these studies. 5 0 obj Discard any unused portion of the reconstituted solution.Store diluted infusion solution under refrigeration at 2° to 8°C (36° to 46°F) for no longer than 24 hours.

Granulocytopenia (neutropenia) usually occurs during the first or second week of treatment but may occur at any time during treatment. Advise patients that fertility may be impaired with the use of CYTOVENE-IV [seeCYTOVENE-IV may cause fetal toxicity when administered to pregnant women based on findings in animal studies. Colony-stimulating factors have been shown to increase neutrophil and white blood cell counts in patients receiving CYTOVENE-IV solution for treatment of CMV retinitis.Due to the frequency of neutropenia, anemia and thrombocytopenia in patients receiving CYTOVENE-IV [seeCYTOVENE-IV should be used with caution in patients with impaired renal function because the half-life and plasma/serum concentrations of ganciclovir will be increased due to reduced renal clearance. The mean [95% CI] and median [95% CI] times to progression of CMV retinitis, as assessed by masked reading of fundus photographs, were 51 days [44, 57] and 41 days [31, 45], respectively, for patients on oral therapy compared to 62 days [52, 72] and 60 days [42, 83], respectively, for patients on intravenous therapy. |��Q{C Patients with impaired renal function may have increased concentrations of ganciclovir and the coadministered drug following concomitant administration of CYTOVENE-IV and drugs excreted by the same pathway as ganciclovir.

Free ... are candidates for antiviral agents such as ganciclovir or valganciclovir.

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