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Afatinib is a P-glycoprotein (P-gp) substrate and cobicistat is a P-gp inhibitor; coadministration may increase plasma concentrations of afatinib. We link directly to the manufacturer and access is completely free. No dose adjustment if CrCL > 50 ml/min. If patient has been on protease inhibitor (other than unboosted atazanavir) for more than 10 days, start bosentan at 62.5 mg daily or every other day. Manufacturer Drug Coupons: Prescription and Non-Prescription. Do not stop taking except on your doctor's advice. Do not coadminister if using sildenafil for pulmonary arterial hypertension.Initiate sildenafil at 25 mg QOD-QD; adjust dose as indicated; not recommended to exceed 25 mg in a 48 hour periodInitiate sildenafil at 25 mg QOD-QD; adjust dose as indicated; not recommended to exceed 25 mg in a 48 hour period For erectile dysfunction, initiate sildenafil 25 mg every 48 hours and monitor for adverse effects. Take your medicine at regular intervals. Visit your doctor or health care professional for regular check ups. Use with caution. Monitor adverse effects and consider therapeutic drug monitoring. Do not coadminister if using sildenafil for pulmonary arterial hypertension.For erectile dysfunction, initiate sildenafil 25 mg every 48 hours and monitor for adverse effects. This will allow quick identification of new safety information. Avoid concomitant use if CrCl < 50ml/min. Start low and titrate bosentan to effect. Monitor for toxicity. Monitor for amiodarone toxicity. This list may not describe all possible interactions. The manufacturer of afatinib recommends permanent discontinuation of therapy for severe or intolerant adverse drug reactions at a dose of 20 mg per day, but does not address a minimum dose otherwise. If patient has been on elvitegravir/cobicistat for more than 10 days, start with bosentan dose of 62.5 mg daily or every other day. Avoid concomitant use if CrCl < 50ml/min. Do not coadminister if using sildenafil for pulmonary arterial hypertension. Consider obtaining ECG and monitoring amiodarone levelsUse with caution. This medicine is not a cure for HIV. It may not cover all possible information. This list may not describe all possible side effects. Skipping doses may make the HIV virus resistant to this medicine and other medicines. ELVITEGRAVIR; COBICISTAT; EMTRICITABINE; TENOFOVIR ALAFENAMIDE (el vye TEG ra veer; koe BIS i stat; em tri SIT uh bean; te NOE fo veer) is 3 antiretroviral medicines and a medication booster in 1 tablet. Monitor digoxin level and adjust digoxin dose based on clinical signs and drug levels.Digoxin dose may need to be decreased. Consider ECG and amiodarone drug level monitoringUse with caution; monitor amiodarone adverse effects. sought to compare the. Consider alternative anticoagulantAvoid coadministration. Consider alternative anticoagulantAvoid coadministration. Avoid concomitant use if CrCl < 50ml/min.No dose adjustment if CrCL > 50 ml/min. Consider alternative anticoagulantAvoid coadministration. The pricing estimates given are based on the most recent information available and may change based on when you actually fill your prescription at the pharmacy*Average and up to savings percentages are based on all discount prescriptions that were run through the WellRx program in 2019. Others use with caution; monitor amiodarone adverse effects. Wait 10 days and then resume bosentan starting with 62.5 mg daily or every other day. Do not take your medicine more often than directed. If patient is currently on bosentan and requires a PI (other than unboosted atazanavir), stop bosentan for at least 36 hours prior to initiating ART. Discount percentages represent savings provided off of pharmacies’ retail prices for consumers who do not have a discount program & pay cash.The day supply is based upon the average dispensing patterns or the specific drug and strength. Wait 10 days and then resume bosentan starting with 62.5 mg daily or every other day. Avoid concomitant use if CrCl < 50ml/min.No adjustment necessary if CrCl > 50 ml/min. Although current manufacturer recommendations ar e avail-able for administering pantoprazole oral suspension packets, none exist for the tablet. If patient is currently on bosentan and requires a PI (other than unboosted atazanavir), stop bosentan for at least 36 hours prior to initiating ART. Use with other PIs with caution; monitor for propafenone toxicityUse with caution.

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