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[30] Additional trials are needed to evaluate the activity of paclitaxel-containing combination regimens in small-cell lung cancer and establish its role in treating this disease. Semin Oncol 23:1, 1996.

The median survival time also increased from 10.6 to 11.1 months when cyclophosphamide and vincristine were added. 15.

These multiple approaches and new combination chemotherapy regimens may further determine the ability of systemic therapy that includes carboplatin to improve survival in patients with small-cell lung cancer and, potentially, to cure those with limited disease. Ellis PA, Talbot DC, Priest K, et al: Dose intensification of carboplatin and etoposide as first-line combination chemotherapy in small-cell lung cancer. 20.

Wolff AC, Ettinger DS, Neuberg D, et al: Phase II study of ifosfamide, carboplatin, and oral etoposide chemotherapy for extensive-disease small-cell lung cancer: An Eastern Cooperative Oncology group pilot study.

Moreover, using AUC rather than toxicity to measure carboplatin exposure minimizes the influence of previous or concurrent myelosuppressive therapy.

Carboplatin appears to have a linear pharmacokinetic profile over the doses used clinically and does not interact significantly with drugs that are used commonly in combination chemotherapy. The importance of standardizing the carboplatin dose based on renal function cannot be overlooked in future trials. [2] Overall response rates of 85% to 95% and 75% to 85% can be expected in patients with limited and extensive disease, respectively. Epub 2020 Feb 20.Kirsch M, Weisse C, Berent A, Clifford C, Leibman N, Wittenburg L, Solomon SB, Lamb K.Clin Pharmacokinet.

[7] Approximately 70% of an administered carboplatin dose is excreted in the urine, and renal clearance of carboplatin correlates closely with the glomerular filtration rate (GFR). J Clin Oncol 13:1430-1435, 1995. 一部壊れているものの、まだ姿はある。 投稿者 hamada : January 28, 2004 11:59 AM Patients assigned to the two-drug regimen received etoposide 200 mg/m² on days 1 through 3 and vincristine 1.4 mg/m² (maximum, 2 mg) on days 1 and 8.

The calculation for BSA should be standardised and the same method used by all clinicians at the institution.

The ICE-containing regimens produced overall response rates of 79% to 94% in patients with limited disease. This is known as one Cycle. Seventy-five patients with previously untreated extensive disease were evaluable. [10-15] Median survival has been as long as 15 months in limited-disease patients and 12 months in those with extensive disease. [2,6] This has led to the development and investigation of combination regimens that have more tolerable toxicity profiles. Semin Oncol 19:12-15, 1992. [5,7] Phase I and II trials of carboplatin as single-agent treatment for small-cell lung cancer resulted in overall response rates of approximately 60% for previously untreated patients and 17% for those who had received prior therapy. Phase I and II trials of carboplatin as single-agent treatment for small-cell lung cancer resulted in overall response rates of approximately 60% for previously untreated patients and 17% for those who had received prior therapy. J Clin Oncol 13:1615-1622, 1995. [3] These poor survival rates are a result of the advanced disease stage at diagnosis, the high recurrence rates associated with local therapy, and the inability of combination chemotherapy to prolong survival significantly. The reduced toxicity and equivalent efficacy of carboplatin have resulted in the increased use of carboplatin-based regimens to treat small-cell lung cancer.

Lung Cancer 9:551-567, 1993. 24. Bunn PA Jr: Clinical experiences with carboplatin (Paraplatin) in lung cancer (suppl 2). [2] Unfortunately, due to its aggressive nature and rapid rate of proliferation, small-cell lung cancer is usually quite advanced at diagnosis.

In patients with extensive disease, overall response rates ranged from 71% to 100%.

Small-cell lung cancer (SCLC) accounts for approximately 17% to 25% of all lung cancers. Disease stage was classified as limited or extensive according to the Veterans Administration Lung Group criteria. Both unbound species have similar pharmacokinetic profiles for the first 12 hours post-dose. Vincristine was given on day 14 of each carboplatin course in an attempt to prevent between-course relapse.

In adults, perhaps the most common method is that of Calvert which describes the relationship between dose and AUC. Data from testicular cancer also strongly supports an AUC-response relationship with an increased number of treatment failures with carboplatin AUCs < 5 to 6 mg/ml.min. Cancer 77:63-70, 1996.

J Clin Oncol 8:899-905, 1990. Hainsworth JD, Gray JR, Hopkins LG, et al: Paclitaxel (1-hour infusion), carboplatin, and extended schedule etoposide in small-cell lung cancer (SCLC): A report on 117 patients (pts) treated by the Minnie Pearl Cancer Research Network (abstract 1623). The AUC of carboplatin appears to relate more closely to both the therapeutic and the toxic effects of the drug than do doses calculated on the basis of body surface area.

There is another dosing method, that involves body surface area, however, this is not as accurate.

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