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Patient Counseling Information Use … After 15 days of amantadine 100 mg b.i.d., the Cmax was 0.47 ± 0.11 µg/mL in four of the five volunteers. (see Deaths have been reported from overdose with SYMMETREL (amantadine hydrochloride) . acute lethal dose was 1 Suicide attempts, some of which have been fatal, have been reported in patients treated with SYMMETREL (amantadine hydrochloride) , many of whom received short courses for Patients receiving SYMMETREL (amantadine hydrochloride) who note central nervous system effects or blurring of vision should be cautioned against driving or working in situations where alertness and adequate motor coordination are important.Patients with Parkinson's disease improving on SYMMETREL (amantadine hydrochloride) should resume normal activities gradually and cautiously, consistent with other medical considerations, such as the presence of Because SYMMETREL (amantadine hydrochloride) has anticholinergic effects and may cause SYMMETREL (amantadine hydrochloride) should not be discontinued abruptly in patients with Parkinson's disease since a few patients have experienced a parkinsonian crisis, i.e., a sudden marked clinical deterioration, when this medication was suddenly stopped. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.Dicyclomine hydrochloride is contraindicated in women who are breastfeeding. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range in adults, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.Effects of renal impairment on PK, safety and efficacy of Dicyclomine hydrochloride have not been studied. Ogilvie's syndrome is a clinical disorder with signs, symptoms, and radiographic appearance of an acute large bowel obstruction but with no evidence of distal colonic obstruction.Toxic dilatation of intestine and intestinal perforation is possible when anticholinergic agents are administered in patients with Salmonella dysentery.Caution should be taken in patients with ulcerative colitis. If dizziness or lightheadedness occurs, notify physician.Notify physician if mood/mental changes, swelling of extremities, difficulty urinating and/or Do not take more medication than prescribed because of the risk of overdose. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. A decision to use other antiparkinson drugs may be necessary.Some patients who do not respond to anticholinergic antiparkinson drugs may respond to SYMMETREL (amantadine hydrochloride) . Use is not recommended in nursing mothers.The safety and efficacy of SYMMETREL (amantadine hydrochloride) in newborn infants and infants below the age of 1 year have not been established.Because SYMMETREL (amantadine hydrochloride) is primarily excreted in the urine, it accumulates in the A dose reduction from 160 mg daily to an average daily dose of 90 mg was required in 46% of the patients with side effects who then continued to experience a favorable clinical response; their side effects either disappeared or were tolerated.The following adverse reactions, presented by system organ class in alphabetical order, have been identified during post approval use of Dicyclomine hydrochloride. Visit the Copyright © 2020 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. It should also be used cautiously in patients with fever. SYMMETREL (amantadine hydrochloride) has an onset of action usually within 48 hours.The initial dose of SYMMETREL (amantadine hydrochloride) is 100 mg daily for patients with serious associated medical illnesses or who are receiving high doses of other antiparkinson drugs. 6.SYMMETREL syrup contains 50 mg of amantadine hydrochloride per 5 mL and has the following inactive ingredients: artificial raspberry flavor, citric acid, methylparaben, propylparaben, and sorbitol solution.SYMMETREL (amantadine hydrochloride) is indicated for the SYMMETREL (amantadine hydrochloride) is indicated for SYMMETREL (amantadine hydrochloride) is also indicated in the treatment of uncomplicated There is no clinical evidence indicating that SYMMETREL (amantadine hydrochloride) is effective in the prophylaxis or treatment of The following points should be considered before initiating treatment or prophylaxis with SYMMETREL (amantadine hydrochloride) :SYMMETREL (amantadine hydrochloride) is indicated in the treatment of SYMMETREL (amantadine hydrochloride) is indicated in the treatment of drug-induced extrapyramidal reactions. 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