hydralazine in preeclampsia nexium

No significant fetal or neonatal problems ascribable to drug treatment were noted in the 13 instances in which labetalol was given before delivery.

e timing to achieve control and the required number of doses was not statistically dierent between the 2 groups (Table 3).

Obstet Gynecol 2010;116:1022–6.Menzies J, Magee LA, Li J, MacNab YC, Yin R, Stuart H, et al.

Early prediction of preeclampsia by measurement of kallikrein and creatinine on a random urine sample. In comparison with all other antihypertensives, hydralazine was associated with more of several adverse outcomes: maternal hypotension, placental abruption, adverse effects on fetal heart rate, caesarean section, maternal oliguria, stillbirth (statistical trend only), and low Apgar score at one minute. Hauth JC, Ewell MG, Levine RJ, et al.

Bhorat IE, Naidoo DP, Rout CC, Moodley J (1993) Malignant ventricular User friendly/feasible website-translation of your paper to 50 world’s leading languagesQuality and quick editorial, review and publication processingIndexing at PubMed (partial), Scopus, EBSCO, Index Copernicus and Google Scholar etcThe objective of management of severe hypertension in pregnancy is not for the return of normal blood pressure but rather reduction of blood pressure to a level associated with a decreased risk of end-organ damage including cerebral, cardiac, or renal dysfunction. Articles in any language were included. However, absolute event rates ranged widely within trials, and outcomes showed significant heterogeneity when risk difference was used as the summary statistic.Hydralazine was associated with more maternal side effects (of any sort) and headache than other antihypertensives (40% (10-82%) Any maternal side effect reported in trials that compared hydralazine with other antihypertensivesHydralazine was associated with more palpitations than other antihypertensives (18% (11-81%) Hydralazine was also associated with more maternal tachycardia than other antihypertensives (24% (10-67%) Despite the high prevalence of side effects (in 85 of 227 patients given hydralazine and 61 of 257 patients given other antihypertensives), few women changed drugs because they experienced side effects (3 of 161 changing from hydralazine, 1 of 167 changing from other antihypertensives); the proportion did not differ between groups.In summary, hydralazine was associated with more maternal side effects than labetalol or ketanserin, and more headache, palpitations, and maternal tachycardia than other antihypertensives. An open, randomized comparison of intravenous labetalol versus dihydralazine was conducted in 40 eclamptic subjects in the peripartum period.

Int J Gynaecol Obstet 77: 67-75.blood pressure during pregnancy. Obstet Gynecol 2005;105:246–54.Lindenstrom E, Boysen G, Nyboe J.

STUDY DESIGN: Two hundred women with severe hypertension in pregnancy were randomized to receive hydralazine (5 mg as a slow bolus dose given intravenously, and repeated every 20 min up to a maximum of five doses) or labetalol (20-mg

Starting magnesium should not be delayed in the setting of acute severe hypertension; it is recommended regardless of whether the patient has gestational hypertension with severe features, preeclampsia with severe features, or eclampsia.American College of Obstetricians and Gynecologists.

Nitroglycerin, in low doses, is mainly a having gestational age > 20 weeks uptil weeks (from venodilator and decreases preload but in high last menstrual period or from the last doses it is both an arteriolar and venodilator. Villar J, Betran AP, Gulmezoglu M. Epidemiological basis for the planning of maternal health services.

Although it may be less effective in preventing recurrent severe hypertension, labetalol controlled severe hypertension in 87% of women and was similar to other antihypertensive agents in the need to prescribe further antihypertensives.

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