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-Initial dose: 20 mg by slow IV injection over a 2-minute period -Additional injections of 40 to 80 mg can be given at 10 minute intervals until a desired supine blood pressure is achieved or a total of 300 mg has been used These are excreted both in urine and via the bile into the faeces.Only negligible amounts of the drug cross the blood brain barrier in animal studies.Not applicable since Trandate Injection/Labetalol Injection has been used in clinical practice for many years and its effects in man are well known.Trandate Injection/Labetalol Injection has been shown to be incompatible with sodium bicarbonate injection BP 4.2% w/vType I Glass ampoules: 5 ampoules of 20ml (per pack). Labetalol crosses the placenta barrier and is excreted in breast milk.Labetalol is metabolised mainly through conjugation to inactive glucuronide metabolites.The glucuronide metabolites are excreted both in urine and via the bile into the faeces. Trandate Injection/Labetalol Injection has been administered to patients with uncontrolled hypertension already receiving other hypotensive agents, including beta-blocking drugs, without adverse effects.Halothane and labetalol act synergistically therefore the halothane concentration should not exceed 1-1.5% as profound falls in blood pressure may be precipitated.Following Trandate Injection/Labetalol Injection the blood pressure can be quickly and easily adjusted by altering the halothane concentration and/or adjusting table tilt. A multi-dose vial is a vial of liquid medication intended for parenteral administration (injection or infusion) that contains more than one dose of medication. The expiry date refers to the last day of that month. over 1-2 weeks, if necessary at the same time initiating replacement therapy, to prevent exacerbation of angina pectoris. There is an increased risk of cardiac and pulmonary complications in the neonate in the post-natal period. Close attention must therefore be paid to blood loss and the blood volume maintained. Changes of the dose of oral anti diabetics may be necessary.Extra caution needs to be taken when general anesthesia is used on patients who are treated with beta-blockers. Concomitant use of tricyclic antidepressants may increase the incidence of tremor. The dosage should gradually be reduced, i.e. • Where peripheral vasoconstriction suggests low cardiac output, the use of Trandate Injection/Labetalol Injection to control hypertensive episodes following acute myocardial infarction is contra-indicated.There have been reports of skin rashes and/or dry eyes associated with the use of beta-adrenoceptor blocking drugs. IFIS has also been reported when other alpha-1-blockers were being used, and the possibility of a class effect cannot be excluded. If this does not produce the desired effect, intravenous administration of 8-10 mg glucagon may be considered. • Labetalol has been shown to reduce the uptake of radioisotopes of metaiodobenzylguanidine (MIBG), and may increase the likelihood of a false negative study. Oliguric renal failure has been reported after massive overdosage of labetalol orally. • Labetalol interferes with laboratory tests for catecholamines.Although no teratogenic effects have been demonstrated in animals, labetalol should only be used during the first trimester of pregnancy if the potential benefit outweighs the potential risk. Beta-blockers may reduce placental perfusion.Labetalol should only be used during the pregnancy if the potential benefit for the mother outweighs the potential risk for the foetus.Labetalol is excreted in breast milk in small amounts (approximately 0.004-0.07% of the dose administered to the mother). The total dose should not exceed 200mg. Labetalol crosses the placental barrier and the possibility of the consequences of alpha- and beta-adrenoceptor blockade in the foetus and neonate should be borne in mind. Sometimes these symptoms have developed a day or two after birth. • Uncontrolled, incipient or digitalis refractory heart failure. This needs to be done to avoid a recurrence of hypertensive crisis as a result of the discontinuance of the clonidine treatment. If necessary, doses of 50mg may be repeated at five minute intervals until a satisfactory response occurs. The variability between the subjects in both the control group and the patient group was high (around 2.5 times).In patients with renal dysfunction lower oral dosages of Labetalol may be necessary (See 4.2 section 4.2 “posology and method of administration”, and section 4.4 “Special warnings and precautions for use”)Labetalol did not show any evidence of carcinogenicity in long term studies performed in rats and mice. This site uses cookies. Do not use Trandate Injection after the expiry date which is stated on the carton and the ampoule label.

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