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Her symptoms abated spontaneously over about 8 hours.Hypokalemia, occurring either in isolation or with hypertension, has been reported regularly in a small fraction of patients. Overview Itraconazole for Dogs and Cats.

This antifungal drug is Higher oral dosages (i.e., 600 mg daily) also have been used for such infections, and some clinicians recommend that itraconazole dosages of at least 400 mg daily be used for the treatment of invasive aspergillosis. In August 2001, the UK CSM published a similar alert. Itraconazole can also interact with other medications, such as These signs disappeared rapidly on discontinuation of itraconazole.Studies in dogs and healthy human volunteers have suggested that itraconazole has a negative inotropic effect; the mechanism is unknown.

Itraconazole is only effective against yeast or fungal Subsequent therapy then can be continued at the usual oral dosage of 200-400 mg daily.The manufacturer states that itraconazole therapy should be continued for at least 3 months and until clinical parameters and laboratory tests indicate that the active fungal infection has subsided. Oral itraconazole therapy should be administered for a minimum of 3 weeks in patients with esophageal candidiasis, and should be continued for 2 weeks after symptoms resolve.If itraconazole is used for the treatment of sporotrichosis, some clinicians recommend that adults receive an oral dosage of 100-200 mg once daily for 3-6 months for cutaneous or lymphocutaneous infections or an oral dosage of 200 mg twice daily for 12 months for osteoarticular infections.For the treatment of onychomycosis (tinea unguium) of the toenails (with or without fingernail involvement), the recommended oral dosage of itraconazole capsules is 200 mg once daily for 12 consecutive weeks. Itraconazole is not used in pregnant animals unless as a life-saving

A response to itraconazole in these patients generally is evident within 2-4 weeks; however, relapse may be expected shortly after the drug is discontinued.Data are limited to date regarding the safety of long-term use of itraconazole oral solution (i.e., longer than 6 months). The entire contents of an ampul containing itraconazole injection (250 mg) should be added to the 0.9% sodium chloride injection diluent (50 mL) provided by the manufacturer to provide a solution containing 3.33 mg/mL in a resultant volume of 75 mL.Correct preparation and administration of the itraconazole solution are necessary to ensure maximum safety and efficacy. Department of Microbiology, Medicine and Pathology, School of Medicine & Health Safety and efficacy of IV itraconazole administered for longer than 14 days have not been established, and more prolonged itraconazole therapy should be completed using oral itraconazole capsules.Candidiasis For the treatment of oropharyngeal or esophageal candidiasis, the recommended dosage of itraconazole oral solution should be vigorously swished in the mouth (10 mL at a time) for several seconds and then swallowed. Heart failure and pulmonary oedema have been reported rarely and serious cardiovascular events including arrhythmias and sudden death have been attributed to drug interactions in patients receiving itraconazole (see Interactions, below). You simply complete a consultation form to be reviewed by a doctor.

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By this time, about 67 million patients worldwide had received itraconazole and there had been 75 spontaneously reported cases of suspected heart failure and an additional 63 reports of oedema suggestive of heart failure associated with oral formulations there had been only 1 report of suspected heart failure in the UK. Overall, 43 patients had risk factors or diseases which might confound an association between the use of itraconazole and development of heart failure.Unpublished studies in dogs and humans had suggested a negative inotropic effect with intravenous itraconazole.

Some clinicians state that while the optimal duration of therapy for serious fungal infections has not been established, itraconazole therapy probably should be continued for at least 12 months for disseminated or chronic pulmonary histoplasmosis and for 6-12 months for blastomycosis. Normal Joints Look Like this in Dogs and Cats . veterinarian and discuss any possible interactions with any medications

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