iv torsemide


Urinary sodium excretion rate relative to the urinary excretion rate of Torsemide is less in cirrhotic patients than in healthy subjects (possibly because of the hyperaldosteronism and resultant sodium retention that are characteristic of portal hypertension and ascites). Ninety-six patients were treated in this study; 6/32 treated with Torsemide experienced seizures, 6/32 treated with comparably high doses of furosemide experienced seizures, and 1/32 treated with placebo experienced a seizure.Torsemide can cause sudden alterations of fluid and electrolyte balance which may precipitate hepatic coma in patients with hepatic disease with cirrhosis and ascites. The largest and most consistent cardiovascular outcome benefit has been a reduction in the risk of stroke, but reductions in myocardial infarction and cardiovascular mortality also have been seen regularly.Elevated systolic or diastolic pressure causes increased cardiovascular risk, and the absolute risk increase per mmHg is greater at higher blood pressures, so that even modest reductions of severe hypertension can provide substantial benefit. Monitor volume status and renal function periodically.Torsemide can cause potentially symptomatic hypokalemia, hyponatremia, hypomagnesemia, hypocalcemia, and hypochloremic alkalosis.

Relative risk reduction from blood pressure reduction is similar across populations with varying absolute risk, so the absolute benefit is greater in patients who are at higher risk independent of their hypertension (for example, patients with diabetes or hyperlipidemia), and such patients would be expected to benefit from more aggressive treatment to a lower blood pressure goal.The antihypertensive effects of Torsemide are on the average greater in black patients than in nonblack patients [Torsemide can be used alone or in combination with other antihypertensive agents.The recommended initial dose is 10 mg or 20 mg oral Torsemide once daily.
No data are available to suggest physiological maneuvers (e.g., maneuvers to change the pH of the urine) that might accelerate elimination of Torsemide and its metabolites.

Administer either as slow injection over 2 minutes or as continuous infusion. and formulary information changes. None of the patients experienced serious adverse events or required withdrawal from the study. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.Mayo Clinic does not endorse companies or products.

Similar signs of chronic non-neoplastic renal injury have been reported in high-dose animal studies of other diuretics such as furosemide and hydrochlorothiazide.No mutagenic activity was detected in any of a variety of in vivo and in vitro tests of Torsemide and its major human metabolite. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below.

184430-overview Consider suspending or discontinuing Torsemide [To prevent hypokalemia and metabolic alkalosis, use an aldosterone antagonist or potassium-sparing drug with Torsemide in patients with hepatic disease.When given with aldosterone antagonists, Torsemide also caused increases in sodium and fluid excretion in patients with edema or ascites due to hepatic cirrhosis. In patients with non-anuric renal failure, severe enough to require hemodialysis, chronic treatment with up to 200 mg of daily Torsemide has not been shown to change steady-state fluid retention.

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informational and educational purposes only. Concomitant use of CYP2C9 inducers (e.g., rifampin) increase Torsemide clearance and decrease plasma Torsemide concentrations. Concomitant use of CYP2C9 inhibitors (e.g., amiodarone, fluconazole, miconazole, oxandrolone) can decrease Torsemide clearance and increase Torsemide plasma concentrations.

All rights reserved. School of Pharmacy (Dr. Stringer), University of Colorado Health Sciences Center, Denver, ColoradoDepartment of Emergency Medicine, The University of Missouri‐Kansas City and Truman Medical Center, Kansas City, Missouri.Department of Emergency Medicine, The University of Missouri‐Kansas City and Truman Medical Center, Kansas City, Missouri.Department of Emergency Medicine, University of Colorado Health Sciences Center, Denver, ColoradoSchool of Pharmacy (Dr. Stringer), University of Colorado Health Sciences Center, Denver, ColoradoDepartment of Emergency Medicine, The University of Missouri‐Kansas City and Truman Medical Center, Kansas City, Missouri.Department of Emergency Medicine, The University of Missouri‐Kansas City and Truman Medical Center, Kansas City, Missouri.Department of Emergency Medicine, University of Colorado Health Sciences Center, Denver, ColoradoUse the link below to share a full-text version of this article with your friends and colleagues. If torsemide is administered through an IV line, it is recommended that, as with other IV injections, the IV line be flushed with Normal Saline (Sodium Chloride Injection) before and after administration. Torsemide is given to help reduce the amount of water in the body associated with congestive heart failure, liver disease (cirrhosis), or kidney disease.

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