ketoconazole drug interactions proscar

Ketoconazole tablets, USP are a synthetic broad-spectrum antifungal agent available in scored white tablets, each containing 200 mg ketoconazole base for oral administration. Upon coadministration, the antifungal activity should be monitored and the ketoconazole tablets dose increased as deemed necessary.Potent inhibitors of CYP3A4 (e.g., antivirals such as ritonavir, ritonavir-boosted darunavir and ritonavir-boosted fosamprenavir) may increase the bioavailability of ketoconazole. Interaction studies have only been performed in adults.

Within the first hour after ingestion, activated charcoal may be administered.There should be laboratory as well as clinical documentation of infection prior to starting ketoconazole therapy. Using ketoconazole tablets with other medicines can cause serious side effects.The most common side effects of ketoconazole tablets include nausea, headache, diarrhea, stomach pain, and abnormal liver function tests.These are not all the possible side effects of ketoconazole tablets. Patients should be advised against alcohol consumption while on treatment.

Calcium channel blockers can have a negative inotropic effect which may be additive to those of ketoconazole.

(See If coadministration cannot be avoided, clinical monitoring for signs or symptoms of increased or prolonged effects or side effects of the interacting drug is recommended, and its dosage should be reduced or interrupted as deemed necessary. Ketoconazole is an anti-fungal agent, prescribed for jock itch, athlete's foot and other infections. If clinical responsiveness is insufficient within the expected time, the dose of ketoconazole tablets may be increased to 400 mg (two tablets) once daily.In small numbers of children over 2 years of age, a single daily dose of 3.3 to 6.6 mg/kg has been used.

Because ketoconazole tablets have been associated with serious adverse reactions (see Co-administration of the following drugs with ketoconazole is contraindicated: dofetilide, quinidine, pimozide, cisapride, methadone, disopyramide, dronedarone, and ranolazine. Concomitant administration of ergot alkaloids such as dihydroergotamine and ergotamine Do not use ketoconazole tablets for a condition for which it was not prescribed. changes in the electrical activity of your heart called QT prolongation. Ketoconazole, USP is a white or almost white powder, odorless powder, soluble in acids, with a molecular weight of 531.43.Ketoconazole is a weak dibasic agent and thus requires acidity for dissolution and absorption.Mean peak plasma concentrations of approximately 3.5 mcg/mL are reached within 1 to 2 hours, following oral administration of a single 200 mg dose taken with a meal. Ketoconazole is one of the most potent inhibitors of the cytochrome P450 3A4 isoenzyme (CYP3A4). Ketoconazole is contraindicated in patients who have shown hypersensitivity to the drug.Because of the serious adverse reactions that have been reported in association with ketoconazole, including fatal hepatotoxicity, ketoconazole tablets are not indicated for treatment of onychomycosis, cutaneous dermatophyte infections, or Candida infections.Ketoconazole tablets should be used only when other effective antifungal therapy is not available or tolerated and the potential benefits are considered to outweigh the potential risks.Serious hepatotoxicity, including cases with a fatal outcome or requiring liver transplantation, has occurred with the use of oral ketoconazole.

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