ketorolac dosage evecare

NSAIDs and some other medicines can interact with each other and cause serious side effects. Therefore, Ketorolac Trometamol 10 mg/ml solution for injection is not recommended for use in children under 16 years of age.Contra-indicated in moderate to severe renal impairment; reduce dosage in lesser impairment (not exceeding 60mg/day IV or IM) (see section 4.3).Ketorolac is contraindicated in patients with previously demonstrated hypersensitivity to Ketorolac, any of its excipients, or other NSAIDs and patients in whom aspirin or other prostaglandin synthesis inhibitors induce allergic reactions (severe anaphylactic-like reactions have been observed in such patients). Such reactions have included asthma, rhinitis, angioedema, or urticaria.Ketorolac is contraindicated in patients with active or a history of gastrointestinal bleeding or perforation, related to previous NSAIDs therapy. Patients should also be encouraged to read the NSAID Medication Guide that accompanies each prescription dispensed.In a study involving 12 adult volunteers, oral ketorolac tromethamine was coadministered with a single dose of 25 mg warfarin, causing no significant changes in pharmacokinetics or pharmacodynamics of warfarin. See package insert for ketorolac tromethamine tablets for transition from IV or IM dosing of ketorolac tromethamine (single- or multiple-dose) to multiple-dose oral ketorolac tromethamine.Note: Oral formulation should not be given as an initial dose.Use minimum effective dose for the individual patient.Total duration of treatment in adult patients: the combined duration of use of IV or IM dosing of ketorolac tromethamine and oral ketorolac tromethamine is not to exceed 5 days.When administering ketorolac tromethamine injection, the IV bolus must be given over no less than 15 seconds.

Therefore, ketorolac should not be used in patients who have had operations with a high risk of haemorrhage or incomplete haemostasis. If an NSAID is considered necessary, the lowest effective dose should be used and for the shortest possible duration. Do not use ketorolac tromethamine for more than five days.However, even short-term therapy is not without risk. of body weight (see DOSAGE AND ADMINISTRATION) and for patients with moderately elevated serum creatinine (see WARNINGS). These patients should commence treatment on the lowest dose available. The terminal half-life was 5.6 (4.0 to 7.9) hours (see KINETICS IN SPECIAL POPULATIONS for use of IV dosing of ketorolac tromethamine in pediatric patients).Carefully consider the potential benefits and risks of ketorolac tromethamine and other treatment options before deciding to use ketorolac. Ketorolac Injection Description. The sterile solutions are clear to slightly yellow in color.Ketorolac tromethamine possesses no sedative or anxiolytic properties.The peak analgesic effect of ketorolac tromethamine occurs within 2 to 3 hours and is not statistically significantly different over the recommended dosage range of ketorolac tromethamine. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard.Single overdoses of Ketorolac have been variously associated with abdominal pain, nausea, vomiting, hyperventilation, peptic ulcers and/or erosive gastritis and renal dysfunction which have resolved after discontinuation of dosing.Gastrointestinal bleeding may occur. Steady-state plasma levels are achieved after dosing every six hours for one day. Unlike the prolonged effects from aspirin, platelet function returns to normal within 24 to 48 hours after ketorolac is discontinued.In post-marketing experience, postoperative wound haemorrhage has been reported in association with the peri-operative use of Ketorolac Trometamol 10 mg/ml solution for injection IM/IV. This interaction should be given consideration in patients taking NSAIDs concomitantly with ACE inhibitors and/or angiotensin II receptor antagonists.Carcinogenesis, Mutagenesis, and Impairment of FertilityKetorolac tromethamine was not mutagenic in the Ames test, unscheduled DNA synthesis and repair, and in forward mutation assays.

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