labetalol vs nifedipine in pregnancy tenormin

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A systematic review.Racial/ethnic disparities in obstetric outcomes and care: prevalence and determinants.The classification, diagnosis and management of the hypertensive disorders of pregnancy: a revised statement from the ISSHP.Ethnic differences in cardiovascular drug response: potential contribution of pharmacogenetics.Increasing value and reducing waste in research design, conduct, and analysis.Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the conduit artery function evaluation (CAFE) study.Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian cardiac outcomes trial-blood pressure lowering arm (ASCOT-BPLA): a multicentre randomised controlled trial.Epidemiology of hypertension in African American women.Normal values of urinary albumin and total protein excretion during pregnancy.Comparison between the effects of amlodipine and lisinopril on proteinuria in nondiabetic renal failure: a double-blind, randomized prospective study.Ca2+ channel subtypes and pharmacology in the kidney.CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials.Do labetalol and methyldopa have different effects on pregnancy outcome? Oral nifedipine and intravenous labetalol show similar efficacy in their ability to control hypertensive emergencies of pregnancy, according to new research published in BJOG: An International Journal of Obstetrics & Gynaecology.. Group means and treatment effects were calculated as geometric means and ratios of geometric means given that log transformations were used. Pulse wave analyses were only assessed at 3 sites, which accounts for the reduction in the number of participants presented. 2017 Nov;70(5):915-922. doi: 10.1161/HYPERTENSIONAHA.117.09972. The other authors report no conflictsThe online-only Data Supplement is available with this article at Labetalol and nifedipine are both effective at lowering brachial blood pressure in pregnancy complicated by chronic hypertension.Labetalol reduces brachial diastolic blood pressure more than nifedipine in non-black women.Nifedipine reduces central aortic blood pressure significantly more than labetalol in women of varying ethnicities.Chronic hypertension in pregnancy is associated with adverse maternal and perinatal outcome.The optimal antihypertensive agent(s) is yet to be identified.Ethnic variation in antihypertensive treatment effect in women with chronic hypertension in pregnancy is evident and warrants further exploration.Labetalol and nifedipine demonstrate differing mechanistic treatment effects, and the clinical importance of these requires investigation.This study provides support for a larger definitive trial scrutinizing the benefits and side effects of first-line antihypertensive treatment in pregnant women with chronic hypertension. organization.Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB)Impact of antihypertensive treatment on maternal and perinatal outcomes in pregnancy complicated by chronic hypertension: a systematic review and meta-analysis.Hypertension in pregnancy: diagnosis and management. Of the women meeting all eligibility criteria to enter the study, two thirds consented to participation and 98% completed the study. J.K. Cruickshank is current President of the Artery Society which has had donations from Servier Pharmaceuticals. However, labetalol achieved control significantly more often with the starting dose and had fewer side effects. 2010; (Clinical Guideline 107).Delayed childbearing: more women are having their first child later in life.Preconceptional and maternal obesity: epidemiology and health consequences.Chronic hypertension and pregnancy outcomes: systematic review and meta-analysis.Antihypertensive drug therapy for mild to moderate hypertension during pregnancy.Fall in mean arterial pressure and fetal growth restriction in pregnancy hypertension: a meta-analysis.Less-tight versus tight control of hypertension in pregnancy.The CHIPS randomized controlled trial (Control of Hypertension in Pregnancy Study): is severe hypertension just an elevated blood pressure?2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8).Why do hypertensive patients of African ancestry respond better to calcium blockers and diuretics than to ACE inhibitors and β-adrenergic blockers? The statistical software Stata/SE version 14 for Windows was used for all analyses. Minor side effects were significantly more common in women taking nifedipine compared to labetalol (48% versus 20%, p = 0.04). There was no significant difference in mean birthweight: 2960 g in the labetalol arm versus 2730 g in the nifedipine arm (adjusted mean difference −240 g; −590, 110 g). Maximum blood pressure after randomization was 161/101 mm Hg with labetalol versus 163/105 mm Hg with nifedipine (mean difference systolic: 1.2 mm Hg [−4.9 to … CONCLUSIONS: Both labetalol and nifedipine were effective for control of persistent postpartum hypertension. For binary outcomes, binary regression with a log link was used to calculate risk ratios (RR).

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