levofloxacin pharmacokinetics coreg

You can also search for this author in The pharmacokinetics and safety of oral levofloxacin in HIV-infected individuals receiving concomitant zidovudine [abstract no. Monte Carlo dosing simulations demonstrated that achievement of therapeutic exposures was dependent on renal function, pathogen, and MIC. The pharmacokinetics of oral levofloxacin in HIV-infected individuals with or without concomitant zidovudine [abstract]. The Clinical Pharmacokinetics of Levofloxacin. Mechanistic study of inhibition of levofloxacin absorption by aluminum hydroxide. Eur J Clin Microbiol Infect Dis 1991; 10: 969–71Gaja M, Higa F, Yamashiro T, et al. Absence of an effect of levofloxacin on cyclosporine pharmacokinetics in healthy adult volunteers [abstract]. Plasma concentrations in healthy volunteers reach a mean peak drug plasma concentration (Cmax) of approximately 2.8 and 5.2 mg/L within 1 to 2 hours after oral administration of levofloxacin 250 and 500mg tablets, respectively. A39]. Antimicrob Agents Chemother 1991; 35: 2106–9Nakashima M, Uematsu T, Kanamaru M, et al. 3: 379Saito I, Suzuki A, Saiko Y, et al. Drugs 1993; 45 Suppl. A two-compartment linear model best described the data. It is used to treat a number of bacterial infections including acute bacterial sinusitis, pneumonia, H. pylori (in combination with other medications), urinary tract infections, chronic prostatitis, and some types of gastroenteritis. The objective of this study was to compare the population pharmacokinetics of levofloxacin in critically ill and in non-critically ill patients. Pharmacokinetics: COREG is rapidly and extensively absorbed following oral administration, with absolute bioavailability of approximately 25% to 35% due to a significant degree of first-pass metabolism. Drugs 1987; 33: 346–91Gaitonde MD, Mendes P, House ESA, et al. 3: 188–95Aoki N, Usuda Y, Koda Y, et al. Eur J Clin Pharmacol 1987; 33: 227–30Gisclon LG, Curtin CR, Fowler CL, et al. 1: S138–9Liao S, Palmer M, Fowler CL, et al. Approximately 80% of levofloxacin is eliminated as unchanged drug in the urine through glomerular filtration and tubular secretion; minimal metabolism occurs with the formation of no metabolites possessing relevant pharmacological activity. Chemotherapy 1992; 40 Suppl. 5th International Symposium on New Quinolones; 1994 Aug 25–27: SingaporeChein SC, Chow AT, Fowler CL, et al. A42]. Rapid stereospecific high-performance liquid chromatogrphic determination of levofloxacin in human plasma and urine. Effect of antacids, ferrous sulfate, and ranitidine on absorption of DR-3355 in humans. Single-dose pharmacokinetics of levofloxacin: influence of age and gender [abstract]. Ofloxacin: a review. Renal clearance and total body clearance are highly correlated with creatinine clearance (CLImportant drug interactions exist with aluminium- and magnesium-containing antacids and ferrous sulfate, as with other fluoroquinolones, resulting in significantly decreased levofloxacin absorption when administered concurrently. American Society for Microbiology: Abstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy; 1996 Sep 15–18; New Orleans, 2Okimoto N, Niki Y, Soejima R. Effect of levofloxacin on serum concentration of theophylline. Jpn J Antibiot 1992; 45: 265–9Ito K, Mikamo H, Izumi K, et al. Pharmacokinetics of levofloxacin in patients with impaired renal function. Antimicrob Agents Chemother 1994; 38: 799–804Holland ML, Chien S-C, Corrado ML, et al. Levofloxacin pharmacokinetics have been evaluated in adult and pediatric patients. the 1: S10–4Borner K, Lode H. Biotransformation of certain gyrase inhibitors. These agents should be administered at least 2 hours before or after levofloxacin administration. Chemotherapy 1992; 40 Suppl. Absence of the effect of levofloxacin on warfarin pharmacokinetics and anticoagulation in male volunteers [abstract no. Antimicrob Agents Chemother 1993; 37: 1877–81Perea EJ, Garcia I, Pascual A. American Society for Microbiology: Abstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy; 1996 Sep 15–18: New Orleans, 19Department of Pharmacy Practice, School of Pharmacy, University of Colorado Health Sciences Center, Campus Box C-238, 4200 East Ninth Avenue, Denver, Colorado, 80262, USADrug Metabolism Department, R.W.

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